| Expression of CD40 and CD40L on Peripheral Blood Mononuclear Cells in Patients with Condyloma Acuminatum |
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| 作者姓名： | 刘冬先 江文 陈兴平 陈映玲 杨东亮 |
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| 作者单位： | Department of Dermatology，Department of Dermatology，Department of Dermatology，Department of Dermatology，Division of clinical Immunology Tongji Hospital Medical College Huazhong University of Science and Technology Wuhan 430030 China |
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| 摘 要： | The initiation,development and transforma-tion of condyloma acuminatum(CA)bear a closerelation to the cellular i mmune function ofhost1-3].The CD40and CD40ligands,a couple ofi mportant costi mulatory molecules of the specifici mmune systemin vivo,play an i mportant role inthe activation of Tlymphocytes and the secretionof effective cytokines.To obtaintheinformation a-bout the expression level and explore the clinicalsignificance of CD40and CD40L on peripheralblood mononuclear cells(PMBC…
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| 关 键 词： | CD40 CD40L 外周学 单核细胞 湿疣 |
| 收稿时间： | 2006-02-28 |
Expression of CD40 and CD40L on peripheral blood monoculear cells in patients with condyloma acuminatum |
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| Liu Dongxian,Jiang Wen,Chen Xingping,Chen Yingling,Yang Dongliang.Expression of CD40 and CD40L on Peripheral Blood Mononuclear Cells in Patients with Condyloma Acuminatum[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2006,26(3):378-379. |
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| Authors: | Liu Dongxian Jiang Wen Chen Xingping Chen Yingling Yang Dongliang |
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| Institution: | 1. Department of Dermatology, Tongji Hospital Medical College, Huazhong University of Science and Technology, Wuhan 430030 China
2. Division of clinical Immunology, Tongji Hospital Medical College, Huazhong University of Science and Technology, Wuhan 430030 China |
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| Abstract: | Summary To observe the expression of CD40/CD40L on peripheral blood mononuclear cells (PBMC) in patients with condyloma acuminatum
(CA), flow cytometry was employed to examine the expression of CD40 and CD40L on PMBC in 36 patients with CA and 20 healthy
controls. Our results showed that mean level of CD40 expression in CA patients was significantly lower than that in the controls
(6.58%±2.74% vs 14.81%±6.12%,t=5.703,P<0.05); the average level of CD40L in CA patients was also significantly lower than that in the controls (0.73%±0.54% vs 2.67±2.43%,t=3.532,P<0.05). Our results suggest that the reduced costimulatory interaction of CD40 and CD40L in CA patients may be one of the
important factors responsible for the low cellular immunity.
LIU Dongxian, female, born in 1962, Associate Professor |
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| Keywords: | condyloma acuminatum antigens CD40 CD40 ligand |
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