正清风痛宁片联合美洛昔康治疗骨关节炎的临床研究

目的探讨正清风痛宁联合美洛昔康治疗骨关节炎的临床疗效。方法选取2014年2月—2016年2月隆昌县人民医院收治的骨关节炎患者440例,根据治疗方案的不同分为对照组和治疗组,每组各220例。对照组口服美洛昔康分散片,1片/次,2次/d。治疗组在对照组治疗基础上口服正清风痛宁片,4片/次,3次/d。两组患者均连续治疗4周。观察两组的临床疗效,同时比较两组治疗前后WOMAC评分、肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)、软骨寡基质蛋白(COMP)及基质金属蛋白酶3(MMP-3)的变化情况。结果治疗后,对照组和治疗组的总有效率分别为89.09%、95.45%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者疼痛评分、关节僵硬评分、日常活动评分、综合评分、IL-1β、TNF-α、COMP、MMP-3均显著降低,同组治疗前后差异有统计学意义(P0.05);且治疗组的降低程度优于对照组,两组比较差异有统计学意义(P0.05)。结论正清风痛宁联合美洛昔康治疗骨关节炎具有较好的临床疗效,可明显改善患者的临床症状,降低血清炎性指标,具有一定的临床推广应用价值。

Clinical study on Zhengqing Fengtongning Tablets combined with meloxicam in treatment of osteoarthritis

Objective To explore the clinical observation of Qianlie Shule Capsules combined with Longjin Tongling Capsules in treatment of chronic prostatitis. Methods Patients (83 cases) with chronic prostatitis in Beijing Luhe Hospitial Capital Medical University from December 2014 to December 2015 were randomly divided into control and treatment groups. Each group had 43 cases. The patients in the control group were po administered with Longjin Tongling Capsules, 2 grains/time, three times daily. The patients in the treatment group were po administered with Qianlie Shule Capsules on the basis of the control group, 4 grains/time, three times daily. The patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the changes of NIH-CPSI scores and white blood cell count of prostatic fluid in two groups before and after treatment were compared. ResultsAfter treatment, the total efficacies in the control and treatment groups were 79.1% and 95.3%, respectively, and there were differences between two groups (P < 0.05). After treatment, life quality impact score, micturition symptom scores, pain score, total score, and white blood cell count of prostatic fluid in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Qianlie Shule Capsules combined with Longjin Tongling Capsules has clinical curative effect in treatment of chronic prostatitis, and can improve the clinical symptoms, reduce inflammatory response, which has a certain clinical application value.