尿CTGF检测对早期糖尿病肾病的诊断意义及保元胶囊的干预作用

[目的]通过检测1~3期糖尿病肾病(DN)患者尿结缔组织生长因子(CTGF)水平变化,探讨其对早期DN的诊断意义,及保元胶囊早期防治DN的可能作用机制。[方法]选择本院门诊或住院的1~3期DN患者为研究对象,并设正常对照组。治疗3个月后,检测用药前后各组患者尿CTGF、尿白蛋白排泄率(UAER)、血清肌酐(SCr)、尿肌酐(Ccr)水平变化。[结果]与1期DN组比较:2期DN组患者尿CTGF、SCr水平均明显升高(P0.05)、而UAER水平无统计学意义(P0.05),3期DN组患者尿CTGF、UAER、SCr水平均明显升高(P0.01),两组Ccr水平均明显降低(P0.01)。2、3期DN组患者治疗后,尿CTGF、UAER水平均明显降低(P0.01),Ccr水平均明显升高(P0.01)。[结论]尿CTGF的检测对诊断早期DN具有重要价值,保元胶囊可降低DN患者尿CTGF水平,这可能是其对早期DN患者肾功能保护作用的机制之一。

Diagnostic value of the detection of urinary connective tissue growth factor to early diabetic nephropathy and intervention effect of Baoyuan capsules

[Objective] To discuss the diagnostic value of the detection of urinary connective tissue growth factor to early diabetic nephropathy and the intervention effect of Baoyuan capsules. [Methods] To choose stage 1~3 diabetic nephropathy (DN) patients from our hospital for study and establish the normal control group. In the third month, the levels of urinary CTGF, UAER, SCr and Ccr were detected before and after treatments in each group. [Results] As compared to the stage 1 DN patients, the levels of urinary CTGF and SCr were elevated significantly in the stage 2 DN patients(P<0.05), but no significant differences about the level of UAER between the two groups(P>0.05), and the levels of urinary CTGF, UAER and SCr were elevated significantly in the stage 3 DN patients(P<0.01) and the levels of Ccr in both of them were decreased significantly(P<0.01). After the treatments in the stage 2 and 3 DN patients, the levels of urinary CTGF and UAER were decreased significantly(P<0.01) and that of Ccr were improved significantly(P<0.01). [Conclusion] It has the important value to detect the level of urinary CTGF for diagnostic the early DN. Baoyuan capsules could decrease the level of the urinary CTGF, that may be one of the renal protection mechanisms to early DN.