止痛消结膏对乳腺增生动物模型的作用

选用健康雌性日本大耳白兔60只,随机分为6组,用雌二醇复制乳腺增生病模型。在制模过程中和制模成功后分别使用止痛消结膏和丙酸睾丸酮软膏外贴乳房部位,对照观察了乳房的大体形态、组织学形态、乳腺上皮细胞的雌激素受体活性和血浆中雌二醇含量。结果提示止痛消结膏能一定程度地抑制和治疗乳腺增生病模型, 能对血将中雌二醇含量和乳腺上皮细胞雌激素受体活性产生一定的影响。

EXPERIMENTAL STUDY ON THERAPEUTIC EFFECT OF ZHITONG XIAOJIE GAO (PAIN-RELIEVING STASISSUBDUING GLU) ON RABBITS WITH EXPERIMENTAL HYPERPLASIA OF MAMMARY GLANDS

60 healthy femaleTapanese big-ear rabbits were selected and divided into 6 groups at random. The rabbit models of hyperblasia of mammary glands were made by injecting dihydrotheelin into these rabbits. During and after the course of making the model, some groups of rabbits were plastered with Zhitong Xiaojie Gao on their breasts and the contro group of them with testosterone propionate ointment on the breasts. The outward appearance and histological structure of the breasts, estrogen recptor activity of epithelial cell of mammary glands, and content of dihydrotheelin in plasma were observed. The result indicated that Zhitong Xiaojie Gao had function to inhibit and treat hyperplasia of mammary glands of rabbit models, and to exert certain influence on the content of dihydrotheelin in plasma and on the estrogen receptor activity of epithelial cell of mammary glands.