Clinical application of NMP22 and urinary cytology in patients with hematuria or a history of urothelial carcinoma |
| |
Authors: | Ming-Yuan Lee Mei-Hua Tsou Mary H. Cheng Daniel S. Chang Alex Lien-Yen Yang Jen-Sheng Ko |
| |
Affiliation: | (1) Department of Pathology and Laboratory Service, Koo Foundation, Sun Yat-Sen Cancer Center, 125 Lih-Der Road, Pei-Tou District, 112 Taipei, Taiwan e-mail: mhtsou@mail.kfcc.org.tw Tel.: +886-2-28970011; Fax +886-2-28972233, TW;(2) Department of Urology, Koo Foundation, Sun Yet-Sen Cancer Center, Taipei, Taiwan, TW;(3) Preparatory Office, National Taiwan University Childrens Hospital, Taipei, Taiwan, TW |
| |
Abstract: | For evaluation of the clinical application of immunoassay for nuclear matrix protein 22 (NMP22 immunoassay) and urinary cytology for early diagnosis and detection of bladder cancer in patients with hematuria and/or a previous history of bladder cancer, 209 urine samples obtained from 137 patients presenting episodes of hematuria or a history of bladder cancer were assayed for NMP22 levels and/or prepared for cytology examination. Biopsy was performed when any visible tumor was identified during cystoscopy examination. The median NMP22 concentrations measured in samples taken from patients with active bladder cancer, from patients with a history of bladder cancer but no active disease, from patients with hematuria, and from healthy volunteers were 18.95, 5.45, 6.39, and 3.75 U/ml, respectively. The urinary NMP22 level recorded for patients with urothelial carcinoma was significantly higher than that noted for individuals without active disease. The sensitivity of the NMP22 assay and of urinary cytology in diagnosing bladder cancer was 69% and 67%, respectively. In contrast, the specificity of these two diagnostic modalities reached 72% and 93%, respectively. The NMP22 assay is slightly more sensitive but less specific than urinary cytology in detecting bladder cancer. This study indicates that determination of urinary NMP22 levels is a useful and noninvasive tool for the detection of bladder cancer because of its high sensitivity. The urinary NMP22 assay may be used as a first-line routine screening method; however, it cannot replace the use of urinary cytology because of its lower specificity. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|