| Ebselen对阿霉素致的小鼠亚急性心、肝、肾组织损伤的保护作用 |
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| 引用本文： | 吴兰,娄宁,周玫,陈瑗.Ebselen对阿霉素致的小鼠亚急性心、肝、肾组织损伤的保护作用[J].基础医学与临床,1996,16(1):49-52. |
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| 作者姓名： | 吴兰 娄宁 周玫 陈瑗 |
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| 作者单位： | 广州第一军医大学自由基医学研究室，广东医学院生物化学教研室 |
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| 摘 要： | 以小鼠为模型，模拟阿霉素临床用药方式，研究具有过氧化物酶样活性的Ｅｂｓｅｌｅｎ的保护作用。通过测定心脏、肝脏、肾脏中脂质过氧化物（ＬｉｐｉｄＰｅｒｏｘｉｄｅｓ，ＬＰＯ）含量、硒谷胱甘肽过氧化物酶（ｓｅｌｅｎｉｕｍ－ｄｅｐｅｎｄｅｎｔｇｌｕｔａｔｈｉｏｎｅｐｅｒｏｘｉｄａｓｅ，ＳｅＧＳＨＰｘ）活性和血清中肌酸磷酸激酶（Ｇｒｅａｔｉｎｅｐｈｏｓｐｈｏｋｉｎａｓｅ，ＣＰｋ）活性及观察各脏器组织学变化，提示Ｅｂｓｅｌｅｎ能提高心肌抗氧化能力，即ｓｅＧＳＨＰｘ／ＬＰＯ比值，降低ＬＰＯ含量，防止和减轻阿霉素对心脏的脂质过氧化损伤。阿霉素对肝脏有轻微的组织学损伤，但完全可以受到Ｅｂｓｅｌｅｎ的保护。阿霉素对肾脏无明显的损伤作用。
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| 关 键 词： | Ebselen，阿霉素，脂质过氧化物，硒谷胱甘肽过氧化物酶，肌酸磷酸激酶 |
Protective EHect of Ebselen on the Heart,Liver and Kidney Tissue from Adriamycin-induced Subacute Tissue Injury in Mice |
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| Wu Lan,Lou Ning,Zhou Mei,Chen Yuan.Protective EHect of Ebselen on the Heart,Liver and Kidney Tissue from Adriamycin-induced Subacute Tissue Injury in Mice[J].Basic Medical Sciences and Clinics,1996,16(1):49-52. |
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| Authors: | Wu Lan Lou Ning Zhou Mei Chen Yuan |
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| Institution: | Free Radical Research Laboratory.First Military Medical University.GuangZhou 510515 |
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| Abstract: | driamycin-inducedsubacute cardio-toxicity occurs mostlikelyvia lipoperoxidative damage to tissues.Ebse-len is a selenorganic compound with Se-glutathione peroxidase-like activity.We tested this compound for its ef-fect on Adr-induced in vivo.The results demonstrared that Ebselen could decrease the content of LPO and ele-vate the ratio of SeGSHPx to LPO in heart tissue significantly.Correspondingly.the change of CPK in serum and the observation of the cross section of every tissue all showed that Ebselen could inhibit lipoperoxidative darnage from Adriamvcin efficiantly. |
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| Keywords: | Ebselen Adriamycin Lipid Peroxides(LPO)Selenium dependent Glutathione Peroxi-dase(SeGSHPx)Creatine Phosphokinase(CPK) |
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