重症肌无力症134例放射治疗的疗效分析

本文回顾分析我院自1961年5月至1985年12月重症肌无力症134例主要采用胸腺放疗的结果。其中25例用深部经X线照射,109例~(60)Co放疗。随访时间2月至24年。完全缓鲜26例(19.5％),显著好转63例(47％),合计显效率为66.5％。56例仅接受放疗或同时服用抗胆碱酯酶剂,可以作为组内自身对照,证实放疗疗效较好。胸腺区或脾区放疗后患者血清nAchRab及淋巴细胞总数降低,具有抗淋巴细胞作用,能抑制自身免疫应答。如今放射治疗对MG已经不是经验性治疗,而是一种值得推荐的免疫调整治疗方法。本文初步提出治疗适应证。

ANALYSIS OF THE EFFICACY OF RADIATION THERAPY IN 134 CASES OF MYASTHENIA GRAVIS

From May, 1961 to December, 1985, 25 patients with myasthenia gravis (MG) were treated by radiation with deep X-ray and 109 patients with 60Co mainly on the thymus, followed up from 2 months to 24 years.89 cases(66.5%)showed good results. complete remission was seen in 26 cases(19.5%)and considerable improvement in 63 cases(47%). 56 cases were treated only by radiation or by combination of radiation and anticholinesterase drugs as self control in this group. Radiation therapy also demonstrated a favourable result.The titers of nAChRab and total lymphocytes in the blood were decreased after irradiation on the thymus or spleen.Nowadays, the radiation therapy for MG is not an empiric treatment,but really one of the immunological regulatory therapies. It may be recommended in clinical practice and its indications have been suggested.