血清单核细胞趋化因子-1、高密度脂蛋白胆固醇水平与冠状动脉病变严重程度的关系

目的：通过检测健康对照组及冠心病人群血清高密度脂蛋白胆固醇（HDL-C）、ApoA1及单核细胞趋化因子-1（MCP-1）水平,探讨冠心病患者HDL-C、ApoA1、MCP-1水平与冠脉病变严重程度的关系。方法：2007年10月～2009年8月于本科行冠脉造影或冠脉CT患者195例,入院前均未行调脂治疗。按冠脉造影或冠脉CT结果分为健康对照组45例,冠心病患者150例,其中急性冠脉综合征109例。入院当时检测血清脂因子、FIB、单核细胞趋化因子-1（MCP-1）、高敏C反应蛋白（hs-CRP）水平。结果：Spearman相关分析显示的MCP-1增高,HDL-C、ApoA1降低与冠脉病变严重程度具有明显相关性。结论：冠心病患者血清炎症因子MCP-1升高,并且与冠脉严重程度呈正相关;HDL-C、ApoA1水平与冠脉严重程度负相关。表明对冠心病患者进行上述指标检测有助于判断患者预后,指导治疗。

Clinical characteristics of the correlation between serum monocyte chemoattractant protein -1 ,high density lipoprote-cholesterol levels and the severity of coronary atherosclerosis

Objective：To investigate serum high density lipoprotein-cholesterol（HDL-C） and monocyte chemoattractant protein-1（MCP-1） levels in patients with coronary heart disease（CHD） and normal coronary angiograms（no-CHD group） and their correlations with the severity and extent of CHD.Methods：195 pateins from October 2007 to August 2008 were divided into two groups according to coronary artery angiography（CAG）,150 cases with CHD and 45 cases with normal coronary angiograms（no-CHD group）,109 patients with ACS among them.Serum HDL-C and MCP-1 levels were measured at once coming into the hospital.Results：Serum HDL-C were significantly lower in the CHD groups than in no-CHD groups.In patients with CHD,the Gensini score correlated inversely with serum HDL-C levels.Serum MCP-1 levels were positively correlated with the Gensini score.Conclusion：The results indicate that HDL-C and MCP-1 may be useful markers of the severity of coronary atherosclerosis in patients with CHD.