Single versus double insemination: a retrospective audit of pregnancy rates with two treatment protocols in donor insemination |
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Authors: | Deary AJ; Seaton JE; Prentice A; Morton NC; Booth AK; Smith SK |
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Institution: | Division of Reproductive Medicine, Rosie Maternity Hospital, Cambridge, UK. |
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Abstract: | Our objective was to evaluate the effect of a change in treatment
protocols, suggested following an inspection visit by the regulatory
authority, from single to double inseminations during donor insemination
treatment cycles. We therefore conducted a retrospective audit of pregnancy
rates in the reproductive medicine clinic of a major teaching hospital. All
patients were treated for male factor infertility by donor insemination,
without ovulation induction with gonadotrophins between October 1992 and
December 1995. The main outcome measures were cumulative conception and
live birth rates. During the study period 250 patients underwent treatment
and 650 single insemination and 277 double insemination treatment cycles
were undertaken. The pregnancy rate per cycle was 0.054 and 0.119 for
single and double insemination respectively. After six cycles the
cumulative pregnancy rates were 0.28 and 0.47 and the take-home baby rates
were 0.25 and 0.37 for single and double inseminations respectively. The
change in practice from single to double insemination resulted in a
doubling of the pregnancy rate per treatment cycle. Cumulative pregnancy
rates after two treatment cycles of double insemination were comparable
with those achieved after six cycles of single insemination. These results
have significant implications for both patients and purchasers.
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