The nonfunctional allele TCRBV6S1B is strongly associated with Helicobacter pylori infection |
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| Authors: | Kunstmann E Hardt C Elitok E Harder M Suerbaum S Peitz U Schmiegel W Epplen J T |
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| Institution: | Department of Molecular Human Genetics, Ruhr-University, 44780 Bochum, Germany. Erdmute.M.Kunstmann@rurh-uni-bochum.de |
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| Abstract: | To determine genetic susceptibility factors for Helicobacter pylori infection, polymorphic T-cell receptor gene elements were investigated in 203 H. pylori-infected individuals and 180 uninfected individuals (controls). H. pylori infection is highly associated with individuals homozygous for the nonfunctional TCRBV6S1B element (odds ratio = 5.9; chi(2) = 13; P = 0.00032; P value corrected for multiple comparisons Bonferroni correction] = 0. 00063). |
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