正交试验优选盐酸川芎嗪脂质体的制备工艺

目的:优选盐酸川芎嗪脂质体的制备工艺。方法:以乙醚注入法制备川芎嗪脂质体,采用正交试验,以包封率为指标,以药物与大豆卵磷脂用量比、PBS缓冲液的pH值、胆固醇与大豆卵磷脂用量比、乙醚与PBS缓冲液用量比为考察因素,优选制备工艺。结果:最佳工艺条件为药物:大豆卵磷脂为1:12,PBS缓冲液pH为7.5,胆固醇:大豆卵磷脂为1:2,乙醚:PBS缓冲液为1:2。结论:该制备工艺可行、稳定、重现性好,可为工业化生产提供理论依据。

Optimization of the Preparation Technology of Ligustrazine Hydrochloride Liposome by Orthogonal Design

OBJECTIVE:To optimize the preparation technology of ligustrazine hydrochloride liposome.METHODS:The liposomes were prepared by ether injection method.The preparation technology was optimized by orthogonal design with encapsulation coefficency as index using ratio of drugs to soybean lecithin,pH value of PBS buffer solution,ratio of cholesterol to soybean lecithin and ratio of diethyl ether to buffer solution as factors.RESULTS:The ideal preparation technology was as follows:drug:soybean lecithin=1:12,pH val...