| 依托泊苷固体脂质纳米粒的研制 |
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| 引用本文： | 于莲,赵向男,崔丹,杜妍.依托泊苷固体脂质纳米粒的研制[J].中国药房,2011(33):3118-3120. |
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| 作者姓名： | 于莲 赵向男 崔丹 杜妍 |
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| 作者单位： | 佳木斯大学药学院黑龙江省高校生物药制剂重点实验室; |
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| 摘 要： | 目的:制备依托泊苷固体脂质纳米粒(ET-SLN)并考察其药剂学性质。方法:采用乳化-超声分散法制备ET-SLN,以单硬脂酸甘油酯(A)、大豆磷脂(B)、泊洛沙姆188(C)、依托泊苷(D)的处方用量为考察因素,包封率为指标设计正交试验,筛选最优处方。考察纳米粒的粒径、表面电位、包封率、体外释放情况等。结果:A、B、C、D分别为0.020、0.010、0.015、0.015mg;所制纳米粒平均粒径(83±0.5)nm,表面电位(-23±0.3)mV,包封率81.2%,可持续48h缓释。结论:所制ET-SLN符合药剂学性质要求。
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| 关 键 词： | 依托泊苷 固体脂质纳米粒 制备 正交设计 处方 |
Preparation of Etoposide Solid Lipid Nanoparticles |
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| YU Lian,ZHAO Xiang-nan,CUI Dan,DU Yan.Preparation of Etoposide Solid Lipid Nanoparticles[J].China Pharmacy,2011(33):3118-3120. |
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| Authors: | YU Lian ZHAO Xiang-nan CUI Dan DU Yan |
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| Institution: | YU Lian,ZHAO Xiang-nan,CUI Dan,DU Yan(Heilongjiang Province Key Laboratory of Biological Medicine Formulation,College of Pharmacy,Jiamusi University,Jiamusi 154007,China) |
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| Abstract: | OBJECTIVE:To prepare Etoposide-loaded solid lipid nanoparticles(ET-SLN) and to investigate the physical and chemical properties.METHODS:Emulsion-ultrasonic dispersion method was used to prepare ET-SLN.The formula was optimized by orthogonal test with amount of glycerin monostearate(A),soy lecithin(B),poloxamer 188(C),etoposide(D) as factors using encapsulation coefficency as index.The particle size,Zeta potential,encapsulation efficiency and in vitro release of the ET-SLN were investigated.RESULTS:Amounts o... |
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| Keywords: | Etoposide Solid lipid nanoparticles Preparation Orthogonal design Formula |
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