| 肾移植术后TOR-I替代CNI免疫抑制治疗的Meta分析 |
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| 引用本文： | 吴斌,吴逢波,卢静,于磊,唐尧. 肾移植术后TOR-I替代CNI免疫抑制治疗的Meta分析[J]. 中国药房, 2011, 0(34): 3229-3231 |
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| 作者姓名： | 吴斌 吴逢波 卢静 于磊 唐尧 |
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| 作者单位： | 四川大学华西医院药剂科;四川大学华西药学院; |
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| 摘 要： | 目的:评价肾移植术后雷帕霉素靶位抑制剂(TOR-I)替代钙调蛋白抑制剂(CNI)免疫抑制治疗的疗效和安全性。方法:检索Cochrane图书馆及Medline、Embase、SCI、CBM数据库和其他相关文献,对纳入研究进行方法学质量评价和Meta分析。结果:纳入10个随机对照试验,3个A级、7个B级。Meta分析结果显示,2组急性排斥反应和肾小球滤过率差异有统计学意义:RR=1.65,95%CI[1.42,1.93]和WMD=8.04,95%CI[2.45,13.62],患者存活率和移植物存活率差异无统计学意义:RD=-0.00,95%CI[-0.02,0.02]和RD=-0.01,95%CI[-0.04,0.01]。结论:基于当前证据,TOR-I对比CNI在肾移植术后免疫抑制治疗中能提高肾小球滤过率,降低巨细胞病毒感染发生率,不影响患者存活率与移植物存活率;但增加了急性排斥反应发生率和贫血、高胆固醇血症、高甘油三酯血症发生风险。
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| 关 键 词： | 西罗莫司 依维莫司 环孢素A 他克莫司 肾移植 Meta分析 |
Meta-analysis of Immunosuppressive Therapy with Target-of-rapamycin Inhibitor Instead of Calcineurin Inhibitor after Kidney Transplantation Operation |
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| WU Bin,WU Feng-bo,LU Jing,YU Lei,TANG Yao WU Bin. Meta-analysis of Immunosuppressive Therapy with Target-of-rapamycin Inhibitor Instead of Calcineurin Inhibitor after Kidney Transplantation Operation[J]. China Pharmacy, 2011, 0(34): 3229-3231 |
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| Authors: | WU Bin WU Feng-bo LU Jing YU Lei TANG Yao WU Bin |
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| Affiliation: | WU Bin,WU Feng-bo,LU Jing,YU Lei,TANG Yao(Dept. of Pharmacy,West China Hospital of Sichuan University,Chengdu 610041,China) WU Bin(West China School of Pharmacy,Sichuan University,China) |
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| Abstract: | OBJECTIVE:To evaluate the efficacy and safety of target-of-rapamycin inhibitor (TOR-I) instead of calcineurin inhibitor (CNI) for kidney transplant recipients. METHODS:Retrieved from Cochrane Library, Medline, Embase, SCI, CBM databases and relevant journals, methodological quality evaluation and Meta-analysis of included studies were conducted. RESULTS: 10 RCTs were included, 3 were grade A and 7 grade B. Results of Meta-analysis showed that there were significant differences in acute rejection and GFR bet... |
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| Keywords: | Sirolimus Everolimus Cyclosporine Tacrolimus Kidney transplantation Meta-analysis |
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