| 两性霉素B联合抗结核药物治疗结核性脑膜炎合并隐球菌性脑膜炎的疗效观察 |
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| 引用本文： | 银春莲,黄欣欣.两性霉素B联合抗结核药物治疗结核性脑膜炎合并隐球菌性脑膜炎的疗效观察[J].中国药房,2011(36):3415-3416. |
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| 作者姓名： | 银春莲 黄欣欣 |
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| 作者单位： | 南宁市第四人民医院; |
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| 摘 要： | 目的:观察两性霉素B联合抗结核药物治疗结核性脑膜炎合并隐球菌性脑膜炎的临床疗效。方法:将52例结核性脑膜炎合并隐球菌性脑膜炎患者随机均分为治疗组和对照组。2组患者均采用抗结核、降颅内高压、应用激素、保肝等综合治疗。治疗组在综合治疗的基础上给予两性霉素B注射剂,以1mg·kg-1·d-1为首次剂量逐渐递增治疗;对照组在综合治疗的基础上给予氟康唑注射剂200mg·kg-1·d-1,首次剂量加倍。2组均治疗45d,均于治疗期间每周复查脑脊液蛋白量。结果:治疗后治疗组脑脊液蛋白量下降至正常率为84.6%,对照组为57.7%,2组比较差异有统计学意义(P<0.05)。治疗组有5例(19.2%)、对照组有4例(15.4%)发生不良反应,2组比较差异无统计学意义(P>0.05)。结论:两性霉素B联合抗结核药物治疗结核性脑膜炎合并隐球菌性脑膜炎可明显降低脑脊液蛋白量,且不良反应少。
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| 关 键 词： | 结核性脑膜炎 隐球菌性脑膜炎 两性霉素B 氟康唑 疗效 |
Efficacy Observation of Amphoterincin B Combined with Anti-tuberculosis Agents for Tuberculous Meningitis Complicating with Cryptococcal Neoformans Meningitis |
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| YIN Chun-lian,HUANG Xin-xin.Efficacy Observation of Amphoterincin B Combined with Anti-tuberculosis Agents for Tuberculous Meningitis Complicating with Cryptococcal Neoformans Meningitis[J].China Pharmacy,2011(36):3415-3416. |
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| Authors: | YIN Chun-lian HUANG Xin-xin |
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| Institution: | YIN Chun-lian,HUANG Xin-xin(Nanning Municipal Forth People's Hospital,Nanning 530023,China) |
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| Abstract: | OBJECTIVE:To observe the clinical efficacy of amphoterincin B combined with anti-tuberculosis agents for tuberculous meningitis complicating with cryptococcal neoformans meningitis.METHODS:52 tuberculous meningitis patients with cryptococcal neoformans meningitis were randomly divided into treatment group and control group with each group of 26 cases.Both 2 groups were given therapy of anti-tuberculosis,lowering intracranial hypertension,glucorticoids,hepatoprotectives and heteropathy.Treatment group was ad... |
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| Keywords: | Tuberculous meningitis Cryptococcal neoformans meningitis Amphoterincin B Fluconazole Therapeutic efficacy |
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