病毒性心肌炎患儿心肌肌钙蛋白T和高敏C-反应蛋白及其检测的意义

目的 探讨儿童病毒性心肌炎(VMC)血清心肌肌钙蛋白T(cTnT)和高敏C反应蛋白(hs-CRP)的变化及临床意义.方法 测定40例VMC患者cTnT、hs-CRP和肌酸激酶同功酶(CK-BM)水平.结果 VMC组人院时血清cTnT、hr-CRP和CK-MB水平明显高于对照组(P<0.01),治疗2周后cTnT、hr-CRP和CK-MB明显降低(P<0.01);入院时cTnT和hs-CRP阳性检出率明显增高,治疗2周后阳性检出率明显降低,cTnT和hs-CRP阳性检出率明显高于CK-MB(P<0.05).结论 检测血清cTnT和hs-CRP足诊断VMC的敏感指标,cTnT和hs-CRP对VMC病情预测亦具重要作用.

Detection of cardiac troponin and high-sensitivity C reactive protein in children with viral myocarditis

OBJECTIVE: To investigate the changes of cardiac T troponin (cTnT) and high-sensitivity C reactive protein (hs-CRP) in children with viral myocarditis (VMC). METHODS: Forty children with VMC were examined for cTnT, hs-CRP, and creatine kinase MB (CK-MB) levels. RESULTS: Children with VMC had significantly higher cTnT, hs-CRP and CK-MB levels than the control group on admission (P<0.01), but obviously decreased after two weeks of treatment. The positivity rate of cTnT and hs-CRP were significantly higher in children with VMC than the control group on admission, and decreased significantly after treatment (P<0.01). The positivity rate of cTnT and hs-CRP were significantly higher than that of CK-MB (P<0.05). CONCLUSION: Serum cTnT and hs-CRP are sensitive indices for diagnosis of VMC, and their detection have important value in estimation of the patients' condition.