| 棓丙酯注射液对高脂血症大鼠血脂代谢影响 |
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| 引用本文： | 孙玉坤,姚辉,唐哲,刘彦生,惠福海.棓丙酯注射液对高脂血症大鼠血脂代谢影响[J].武警医学院学报,2013,22(4):267-269. |
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| 作者姓名： | 孙玉坤 姚辉 唐哲 刘彦生 惠福海 |
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| 作者单位： | 1. 武警辽宁总队医院药剂科,辽宁沈阳,110034
2. 沈阳药科大学生命科学与生物制药学院,辽宁沈阳,110016 |
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| 摘 要： | 【目的】探讨棓丙酯注射液对高脂血症大鼠的血脂调节作用。【方法】棓丙酯注射液13、26、52 mg.（kg.d）-1给大鼠连续腹腔注射4周,测定大鼠体重和血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）的含量,同时对大鼠进行肝功能检查。【结果】棓丙酯注射液能明显降低实验性高脂血症大鼠TC、TG、LDL-C及过氧化脂质（LPO）含量,明显提高HDL-C含量及超氧化物歧化酶（SOD）活性。【结论】棓丙酯注射液对高脂血症大鼠降血脂作用明显,能有效调节机体脂质代谢,对治疗高脂血症有一定的作用。
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| 关 键 词： | 棓丙酯 高脂血症 大鼠 |
Effect of propylgallate Injection on experimental hyperlipidemia in rats |
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| SUN Yu-kun
,
YAO Hui
,
TANG Zhe
,
LIU Yan-sheng
,
HUI Fu-hai.Effect of propylgallate Injection on experimental hyperlipidemia in rats[J].Acta Academiae Medicinae CPAPF,2013,22(4):267-269. |
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| Authors: | SUN Yu-kun YAO Hui TANG Zhe LIU Yan-sheng HUI Fu-hai |
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| Institution: | (Department of Pharmacy, Liaoning Provincial Crops Hospital, Chinese of People＇s Armed Police Forces, Shenyang 110034, China) |
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| Abstract: | Objective] To explore the effect of propylgallate injection on experimental hyperlipidemia in rats. Methods] Hyperlipemia rats were given propylgallatc injection 13, 26, 52 mg. （kg. d）^-1 respectively by intraperitoneal injection, for 4 weeks.Body weight,serum level of total cholesterol （TC）,triglyceride （TG）,low density lipoprotein cholesterol （LDL-C）, high density lipoprotein cholesterol （HDL-C）, and liver function were measured at the end of the experiment. Results] TC, TG, LDL-C and lipidperoxidatio （LPO） contents were signifieandy decreased,and HDL-C contents and superoxidedismutas （SOD）activity were significantly increased. Conclusion ] Propylgallate injection can regulate lipid metabolism effectively,treat hyperlipidemia definitely. |
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| Keywords: | Propylgallate Hyperlipidemia Rats |
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