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Bone marrow ablation followed by allogeneic marrow grafting during first complete remission of acute nonlymphocytic leukemia
Authors:Forman  SJ; Spruce  WE; Farbstein  MJ; Wolf  JL; Scott  EP; Nademanee  AP; Fahey  JL; Hecht  T; Zaia  JA; Krance  RA; Findley  DO; Blume  KG
Abstract:Of 33 patients who had undergone allogeneic bone marrow transplantation during first complete remission of acute nonlymphocytic leukemia, 21 patients have now been followed in continued complete remission for 6- 64 mo (median greater than 18 mo) without maintenance chemotherapy. The median age of the surviving patients is 27 yr. Transplant-related complications occurring throughout the first year after marrow grafting were fatal in 7 patients, and leukemic recurrence led to the death of 5 patients. The actuarial long-term disease-free survival is 60% and the actuarial remission rate is 79%.
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