Albumin extravasation in bicuculline-induced blood-brain barrier dysfunction |
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| Authors: | Lennart I. Persson Lars E. Rosengren Barbro B. Johansson |
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| Affiliation: | Department of Neurology, University of Göteborg, Göteborg, Sweden |
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| Abstract: | The extravasation of endogeneous rat albumin and exogeneous 125I-labeled human serum albumin was compared in rats subjected to bicuculline-induced blood-brain barrier dysfunction.
The correlation between rocket immunoelectrophoretic assays of endogeneous rat albumin and 125I-labeled human serum albumin, assayed by gamma scintillation counting, was good irrespective of whether 125I-labeled albumin was studied in whole brain tissue or in brain homogenates. The ratio of brain to serum albumin was similar with the two assay methods. |
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| Keywords: | Albumin bicuculline blood-brain barrier hypertension 125IHSA rocket immunoelectrophoresis |
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