| 糖尿病视网膜病变中内质网应激和HIF-1对VEGF的调控机制研究进展 |
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| 引用本文： | 王 静,朱 鸿,施彩虹.糖尿病视网膜病变中内质网应激和HIF-1对VEGF的调控机制研究进展[J].上海交通大学学报(医学版),2014(2):240-243. |
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| 作者姓名： | 王 静 朱 鸿 施彩虹 |
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| 作者单位： | [1]上海交通大学医学院附属第三人民医院眼科,上海201900 [2]上海交通大学附属第一人民医院眼科,上海200080 |
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| 基金项目： | 上海市自然科学基金（10ZR1418500）. |
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| 摘 要： | 糖尿病视网膜病变（DR）是糖尿病严重的微血管并发症之一，可导致不可逆的失明，DR的基本病理改变是血一视网膜屏障破坏和新生血管形成，而血管内皮生长因子（VEGF）是公认的最重要的眼内新生血管生长因子。近来研究发现，内质网应激（ERS）和低氧诱导因子-1（HIF-1）能够调控VEGF的表达，共同促进DR的病程发展。该文就ERS和HIF-1对于VEGF的调控机制方面的研究进展进行综述。
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| 关 键 词： | 糖尿病视网膜病变 内质网应激 低氧诱导因子-1 血管内皮生长因子 |
Advances of regulation of endoplasmic reticulum stress and HIF-1 to VEGF in diabetic retinopathy |
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| WANG Jing,ZHU Hong,SHI Cai-hong.Advances of regulation of endoplasmic reticulum stress and HIF-1 to VEGF in diabetic retinopathy[J].Journal of Shanghai Jiaotong University:Medical Science,2014(2):240-243. |
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| Authors: | WANG Jing ZHU Hong SHI Cai-hong |
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| Institution: | 1. Department of Ophthalmology, the Third People＇s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China; 2. Department of Ophthalmology, the First People＇s Hospital, Shanghai Jiao Tong University, Shanghai 200080, China) |
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| Abstract: | Diabetic retinopathy is one of the most severe microvascular complications of diabetes mellitus, which can lead to irreversible blindness. The main pathological changes of DR are breakdown of blood-retinal barrier and neovascularization. Vascular endothelial growth factor （VEGF） is considered to be the most important intraocular neovascularization factor. Recent researches show that endoplasmic reticulum stress （ERS） and hypoxia-inducible factor-1 （HIF-1） can regulate the expression of VEGF and advance the progress of diabetic retinopathy together. This paper reviews the latest advance of the regulation mechanism of ERS and HIF-1 to VEGF. |
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| Keywords: | diabetic retinopathy endoplasmic reticulum stress hypoxia-inducible factor-1 vascular endothelial growthfactor |
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