脑白质疏松症伴发轻度认知功能障碍的临床分析

目的 探讨脑白质疏松症（LA）伴发轻度认知功能障碍（MCI）的相关影响因素.方法 对107例经CT或MRI检查发现LA的患者,根据蒙特利尔认知评价量表（MoCA）评分结果,分为伴轻度认知功能障碍组（MCI组）46例和不伴轻度认知功能障碍组（N-MCI组）61例,分析LA伴MCI的相关影响因素.结果 2组间文化程度、高同型半胱氨酸血症（Hhcy）、抑郁状态、矽肺与LA伴发MCI的发生差异有统计学意义（P＜0.05）,年龄、性别、婚姻状况、经济情况与LA伴发MCI的发生差异无统计学意义（P＞0.05）.结论 发现文化程度低、Hhcy、抑郁状态、矽肺的LA患者更容易产生MCI.

The study of the relevant factors influencing leukoaraiosis with mild cognitive impairment

Objective To investigate the related influencing factors of leukoaraiosis （LA） associated with mild cognitive im pairment. Methods 107 cases were diagnosed as leukoaraiosis by CT or MRI examination,all cases were divided into MCI group （46 cases） and N MCI group （61 cases） according to the montreal cognitive assessment score. Results The Hhcy, depressive state and silicosis had statistically significance （ P 〈 0.05 ） with LA associated with MCI, whereas the age, gender, marital status and economic situ-ation had no statistically significance （P 〉 0.05） with LA associated with MCI. Conclusion This study suggests that the patients are more prone to MCI if they are low levels of education, Hhcy, depressive state or silicosis.