膀胱移行细胞癌组织中脂肪酸合成酶表达及其预后相关性分析

目的:脂肪酸合成酶(fatty acid synthase,FAS)是一种新的肿瘤标志物,高表达常常提示肿瘤的预后不良,本文研究其在膀胱移行细胞癌中的表达及其临床意义。方法:对65名随访5年膀胱移行细胞癌手术患者的石蜡标本进行FAS的免疫组织化学染色分析,并与15例正常膀胱粘膜组织进行对照。结果:与正常组织相比,FAS在膀胱移行细胞癌组织中高表达,阳性表达率58.5%(38/65),有显著性的差异(P<0.05)。FAS的表达与肿瘤分级,初发复发有关(P<0.05)。但与临床分期及肿瘤数目无关。FAS阳性表达患者的5年生存率远低于阴性患者(18%vs44%),有显著性差异(P<0.05)。结论:FAS在膀胱移行细胞癌组织中表达增高,酶活性增强;FAS在膀胱移行细胞癌组织中表达增高有提示不良预后的作用。

Significance of fatty acid synthase expression in bladder transitional cell carcinoma

Objective:Fatty acid synthase(FAS) is a new tumor marker,the high expression which indicates the poor prognosis of cancer,we investigate the expression of Fatty Acid Synthase in transitional cell carcinoma(TCC) in bladder and its clinical significance.Methods:The expression of FAS was detected by streptavidin-peroxidase immunohistochemical method in the paraffin embedded sections of 65 TCC patients with the clinical data analyzed.15 normal bladder tissues were used as control group.Results:The positive rate of the expression of FAS in TCC was 58.5%(38/65),while only 2 of 15 cases in control group expressed FAS protein.The difference was statistical significant.The expression of FAS was related to the histological grades and recurrence but no significant difference was detected in different pathological stages.Survival analysis revealed that the 5-year survival rate was lower in FAS positive patients than in negative patients(18% vs 44%),the result was statistically significant(P<0.05).Conclusion:Fatty acid synthase is over expressed and hyper-activated in TCC and implies poor prognosis.