妥洛特罗贴在小儿毛细支气管炎中的应用

【摘要】 目的 比较妥洛特罗贴与雾化吸入沙丁胺醇在毛细支气管炎中的作用，同时观察药物的不良反应。 方法 选择60例毛细支气管炎患儿，随机分为观察组和对照组（各30例），观察组采用妥洛特罗贴片联合雾化吸入异丙托溴胺、布地奈德治疗；对照组采用雾化吸入沙丁胺醇、异丙托溴胺及布地奈德治疗，比较2组患儿咳嗽、哮鸣音等症状评分及对日常生活和睡眠的影响评分，用药第1天和第7天分别测潮气肺功能，同时检测血、尿常规并观察是否有其他严重不良反应出现。 结果 2组总有效率、咳嗽程度、哮鸣音、排痰情况及对日常生活的影响差异均无统计学意义（P > 0.05），但睡眠质量差异有统计学意义（Z=1.974，P < 0.05）；2组在用药第1天和第7天的潮气量、吸呼比、达峰时间比和达峰容积比差异均有统计学意义（P < 0.05），2组治疗第1天上述各指标差异均无统计学意义（P > 0.05），但观察组达峰时间比和达峰容积比在第7天优于对照比（P < 0.05）；2组治疗前后的WBC及血红蛋白、尿常规差异均无统计学意义（P > 0.05），也未发现其他严重不良反应。 结论 妥洛特罗贴联合雾化吸入异丙托溴胺、布地奈德治疗毛细支气管炎疗效显著，副作用小，依从性好。

Effect of Tulobuterol Patches on Infant Bronchiolitis

【Abstrct】 Objective To compare the effect of tulobuterol patches and nebulized salbutamol on Infant Bronchiolitis，meanwhile observe the medicine adverse reaction. Methods Sixty bronchiohtis infants were randomly divided into observation group and control groups. There were 30 cases in each group. The observation group was given tulobuterol patches combined with nebulization Ipratropium Bromide and budesonide, whereas the control group was given inhalation of salbutamol, Ipratropium Bromide and budesonide. Besides them, other therapies (including Oxygen inhalation, sputum suction, symptomatic and support treatment, the use of antibiotics) had no difference. Symptom scores of the coughing and wheezing, the effect scores of daytime lives and nocturnal sleep and the incidence adverse reactions were recorded. Pulmonary function test were detected on the first day and the seventh day. Blood routine, urine routine and medicine’s side effects were observed also.Results Between two groups, there were no significant difference in the total effect, the level of cough, expectoration, wheezing and the scores of daytime lives（P > 0.05）, but nocturnal sleep was improved significantly（Z=1.974，P < 0.05）. Tidal volume, TI/TE, TPTEF/TE and VPEF/VE had significant difference after treatment in both groups.（P < 0.05）. All of the index were no difference between two groups on the first day. TPTEF/TE and VPEF/VE in observation group were better than those in control group（P < 0.05）. White count and urine routine were not influenced. There was no serious side effect during the treatment. Conclusion Tulobuteml patches combined with nebulized Ipratropium Bromide and budesonide have a certain effect in treatment of infant bronchiohtis，with faster effect，fewer adverse reactions and good compliance．