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CLEARANCE OF NEOSTIGMINE FROM THE CIRCULATION DURING THE ANTAGONISM OF NEUROMUSCULAR BLOCK |
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| Authors: | WILLIAMS, N. E. CALVEY, T. N. CHAN, K. |
| Affiliation: | Whiston Hospital, Prescot, Lancashire Department of Pharmacology and Therapeutics, University of Liverpool Liverpool L69 3BX School of Pharmacy, Liverpool Polytechnic Liverpool L3 3AF |
| Abstract: | The plasma concentration of neostigmine was measured in fivepatients during the antagonism of neuromuscular block. The concentrationof the drug decreased rapidly between 2 and 5 min after administration,and then more slowly. Detectable concentrations of neostigminewere present in plasma after 60 min. In the five patients thedistribution half-life of neostigmine was less than 1 min; theelimination half-life ranged from 15.4 to 30.1 min. |
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