高甘油三酯血症与血凝纤溶系统的关系

为研究脂质代谢紊乱与血浆凝血纤溶活性的关系，分别测定了61例高脂血症患者（混合性高脂血症16例和单纯性高甘油三酯血症45例）的血清脂质和血浆反映凝血纤溶活性的有关指标，并与18例正常人对比。结果发现，高脂血症患者的血浆纤溶酶原激活剂抑制物-1、凝血因子VII和凝血因子X活性明显高于正常对照组（P＜0．05～0．001），组织型纤溶酶原激活物活性明显低于正常对照组（P＜0．05）。血清甘油三酯水平与血浆纤溶酶原激活物抑制剂-1、因子VII和因子X活性是显著的正相关性（P＜0．05～0．001），与组织型纤溶酶原激活物活性是显著的负相关性（P＜0．01）；血清胆固醇水平与血浆纤维蛋白原水平和纤溶酶原激活物抑制剂-1活性呈显著的正相关性（P＜0．05）。结果提示，脂质代谢紊乱，特别是高甘油三酯血症可增加体内凝血活性，降低纤溶活性，有利于血栓形成，对动脉粥样硬化的发生和发展有不利的影响。

The Association of Hypertriglyceridemia with Plasma Haemostatic and Fibrinolytic Activities

Aim To ivestigate the association of lipid metabolism disturbance with haemostatic activity and fibrinolytic activity.Methods Serum lipids,some plasma haemostatic and fibrinolytic parameters were determined in 61 pa-tients with hyperlipidemia(hypertriglyceridemia in 45and mixed hyperlipidemia in 16)and compaerd with those in 18 healthy controls.Results The plasma activities of type-1 plasmino-gen activitor inhibitor(PAI-1),coagulation factor VII (F VII)and X(F X)were significantly higher,tissue type plasminogen activitor(tPA)was significantly lower in hyperlipidemic patients when compared with those in healthy controls(P<0.05~0.001). Fur-thermore serum triglyceride level was positively corre-lated with plasma activities of PAI-1,F VII and F X(P <0.05~0.001),and negatively correlated with tPA activity(P<0.01).Serum cholesterol level was also positively correlated with plasma fibrinogen level and PAI-1 activity(P<0.05).Conclusion Hyperlipidemia,especially hyper-triglyceridemia may increase coagulation activity and decrease fibrinolytic activity,benefiting the formation of thrombosis.Therefore,hyperlipidemia is an im portant risk factor for atherosclerosis.