不同透析膜透析时患者体内脂质过氧化的变化

为探讨不同透析膜透析时氧自由基对维持性血液透析病人可能产生的氧化损伤，对维持性血液透析病人使用铜仿膜。聚砜膜及血仿膜透析．分别检测透析前后血浆和红细胞向二醛、超氧化物歧化酶及全血谷光甘肽过氧化物酶活性，并与健康组对照。结果发现铜仿膜透析后红细胞丙二醛显著增加，超氧化物歧化酶活性显著降低，聚砜膜和血仿膜透析时则变化不明显。此结果提示使用聚砜膜或血仿膜行长期血液透析对防治维持性血液透析病人氧自由基增加而产生的并发症有重要的临床意义。

Changes of Lipid Peroxide Content in Hemodialyzed Patients with Different Membranes

Aim To investigate possible oxidative injuries topatients during hemodialysis process with differentmembranes.Method The levels of malondialdehyde(MDA)andsuperoxide dismutase (SOD) in both plasma and redblood cell, gultathione peroxidase (GPX) in whole blood samples of maintenance hemodialyzed patientswere exanlined before and after dialysis with cupo-phane, polysulphone and hemophan membranes,and were compared with those of health controls.Result A significant increase of MDA level and adecrease of SOD activity after dialysis with cupophane membrane, while no significant differences were ob-served with polysulphone and hemophan membranes.Conclusion The use of polysulphone and hemophan membranes for long term hemodialysis is benefit to Prevention and cure any syndrome caused by the in-crease of peroxide radicals.