结核病控制项目组合药物利用与经济学评价

目的:评价韶关市结核病控制项目组合药物利用情况及其经济学效果。方法:以限定日剂量(DDD)和药物利用指数(DUI)作为评价合理用药的指标,分析韶关市区1993年～2003年结核病控制项目化疗药物利用情况,并对结核病控制项目化疗方案B与常规化疗方案A进行成本-效果比较。结果:除B4 外,其它组合药物DUI≤1。B方案治愈率(E1)为96. 5 % ,有效率(E2)为98. 8 % ;A方案E1、E2 分别为65. 7 %和79 .5 %。B方案的治疗成本-效果比低于A方案,按治愈率计算的成本-效果比(C/E1)分别为8 59、25. 31 ,按有效率计算的成本-效果比(C/E2)分别为8 39、20. 92。结论:韶关市区结核病控制项目组合药物利用比较合理,经济学效果较好。

Utilization of Drug Combination in the Tuberculosis Control Item and the Economics Evaluation

OBJECTIVE:To evaluate the utilization information of drug combination in tuberculosis control item in Shaoguan and the economics effect.METHODS:The defined daily dose(DDD)and drug utilization index(DUI)were taken as indexes for the evaluation of rational use of drugs,the utilization of chemotherapy drugs of the tuberculosis control item in Shaoguan urban field from1993to2003was analyzed;the cost-effectiveness of scheme B(tuberculosis control item chemotherapy)and scheme A(conventional chemotherapy)were analyzed.RESULTS:DUI for all of the drug combinations except B4were no more than1(DUI≤1),The cure rate(E 1 )and the effect rate(E 2 )for scheme B were96.5%and98.8%respectively;E 1 and E 2 in scheme A were65.7%and79.5%respectively.The cost-effectiveness ratio of scheme B was lower than that of scheme A.The cost-effectiveness ratio(C/E 1 )for the two schemes were8.59and25.31respectively if counted by cure rate and which(C/E 2 )were8.39and20.92respectively if counted by effect rate(E2).CONCLUSION:The utilization of tuberculosis control item drug combinations in Shaoguan city is comparatively reasonable and the economic effect is good.