11C-匹兹堡复合物B正电子发射断层摄影术脑显像在阿尔茨海默病早期诊断中的临床应用

目的 探讨N-甲基11C]2-(4'-甲基氨基苯基-6-羟基苯并噻唑){N-methyl11C]2-(4'-methylaminophenyl-6-Hydroxybenzathiazole),11C-PIB}PET脑显像在阿尔茨海默病(AD)早期诊断中的价值.方法 分别对6例AD患者、7例轻度认知功能障碍(MCI)患者及6名智能正常的老年对照者(NC)进行临床诊断、资料收集及11C-PIB PET脑显像,并对5、25和45 min PET图像进行分析.结果 视觉分析:AD患者3个时段放射性清除情况与NC组有明显不同,药物注射45 min后脑内放射性清除较NC组明显减低;MCI组图像呈不均一改变,与AD、NC组均有重叠.统计分析:3组受试者各脑区与小脑45 min标准吸收值(SUV)比值示:AD组顶叶、额叶、颞叶、枕叶及海马比值分别为1.91±0.21、2.09±0.41、1.92±0.35、1.66±0.41、1.55±0.28,高于NC组的1.48±0.53、1.57±0.64、1.36±0.53、1.27±0.40、1.17±0.33,差异具有统计学意义(t值分别为8.114、5.620、5.705、3.650、2.866,P值分别为0.0001、0.0002、0.0002、0.0045和0.0170),MCI组顶叶、额叶、颞叶、枕叶及海马的比值分别为1.48±0.53、1.57±0.64、l_36±0.53、1.27±0.40、1.17±0.33,均高于相应NC组,但差异无统计学意义.结论 11C-PIB PET脑显像能够鉴别早期AD患者与Nc,并对MCI患者有一定预测价值.

Clinical application of positron emission tomography with Pittsburgh compound B in the early diagnosis of Alzheimer's disease

Objective To evaluate the roles of positron emission tomography (PET) with N-methyl 11C]2-(4' -methylaminophenyi-6-hydroxybenzathiazole) (11C-PIB) in the early diagnosis of Alzheimer's disease (AD).Methods Six AD patients,7 mild cognitive impairment (MCI) patients and 6 normal controls (NC) were diagnosed and assessed with brain PET with 11C-PIB.The emission images obtained at 5,25 and 45 min after 11C-PIB administration were analysed.Results Using visual analysis to summarize the characteristics of the imagings of each group: comparing to NC,the AD patients show high 11C -PIB up take,and low clearance rate of 11C-PIB at 45 min.The imagings of MCI group show heterogeneous,overlapping with AD and NC group.The statistical analysis shows: in AD group,the standard uptake value (SUV) ratio of parietal lobe,frontal lobe,temporal lobe,occipital lobe and hippocampal at 45 min was 1.91±0.21,2.09±0.41,1.92±0.35,1.66±0.41,1.55±0.28 respectively,and were higher than that of NC group (value being 1.48±0.53,1.57±0.64,1.36±0.53,1.27±0.40,1.17±0.33) with statistical significance,t=8.114,5.620,5.705,3.650 and 2.866,P=0.0001,0.0002,0.0002,0.0045 and 0.0170 respectively.In MCI group,the SUV ratio of parietal lobe,frontal lobe,temporal lobe,occipital lobe and hippocampal at 45 min was 1.48 ± 0.53,1.57 ± 0.64,1.36±0.53,1.27 ± 0.40,1.17±0.33 respectively,and were higher than that of NC group,but there was no statistical significance.Conclusion 11C-PIB PET imaging can differentiate AD patients from normal and anticipate the transformation of MCI patients.