Assignment of the human cardiac/slow skeletal muscle troponin C gene (TNNC1) between D3S3118 and GCT4B10 on the short arm of chromosome 3 by somatic cell hybrid analysis |
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| Authors: | P. J. TOWNSEND M. H. YACOUB P. J. R. BARTON |
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| Affiliation: | Imperial College School of Medicine at the National Heart and Lung Institute, Dovehouse Street, London SW3 6LY |
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| Abstract: | We have determined the chromosomal location of the human cardiac/slow skeleletal muscle troponin C gene (TNNC1) to the short arm of chromosome 3 using somatic cell hybrids. PCR-based analysis of a 'monochromosomal' hybrid panel identified the presence of the TNNC1 gene on human chromosome 3 and subsequent analysis of the Genebridge4 radiation hybrid panel located the gene between D3S3118 (7·3cR) and GCT4B10 (4·2cR) with a lod score of >3·0. |
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