Tourette综合征的共病临床研究

目的：了解Tourette综合征共病的种类、发生率及相关因素。方法：以CCMD-3诊断标准为依据，分别采用耶鲁综合抽动严重程度量表(YGTSS)、Achenbach儿童行为量表(CBCL)、莱顿(Leyton)强迫量表、康纳(Conners)儿童行为问卷和家庭情况调查表，对125例Tourette综合征逐一进行评定。结果：Tourette综合征与注意缺陷多动障碍共病率为41．6％，与强迫症的共病率为25．6％，与焦虑障碍的共病率为8．0％，与抑郁障碍的共病率为4．8％，与品行障碍的共病率为8．0％，与自伤的共病率为3．2％，与睡眠障碍的共病率为2．4％。结论：Tourette综合征的共病种类多，患病率高，影响TS的治疗及预后。共病通常是TS儿童功能损害的来源，并增加疾病的复杂性和严重性，应该引起高度重视。

A Preliminary Study of Comorbidities Associated with Tourette Syndrome

Objective:To explore the category,prevalence and related factors of comorbidities associated with Tourette syndrome.Methods:125 patients with TS according to CCMD-3(Chinese Classification of Mental Disorders,3rd edition)were assessed with a self-designed family circumstance questionnaire,YGTSS,CBCL,Leyton obsessive-compulsive scale,and Conner's Child Behavior Checklist.Results:Of 125 TS patients,the comorbidities included attention deficit and hyperactivity disorder(ADHD,41.6%),obsessive-compulsive disorder(OCD,25.6%), anxiety disorders(8.0%),depressive disorders(4.8%),conduct disorders(8.0%),self-injurious behavior(3.2%),and sleep disorder(2.4%).Conclusion:There are many kinds of comorbid disorders at high prevalence in TS patients. These comorbidities adversely influence the therapy and prognosis of TS and are taken as the possible reasons for social function deficit.