Kindling-like stimulus patterns induce epileptiform discharges in the guinea pig in vitro hippocampus |
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Authors: | N T Slater A Stelzer M Galvan |
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Institution: | Department of Physiology, University of Munich, Pettenkoferstrasse 12, D-8000 München 2 F.R.G. |
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Abstract: | In the guinea pig in vitro hippocampal slice preparation, we have demonstrated that the repeated tetanic stimulation of the Schaffer collateral-commissural input to CA1 pyramidal neurones produces a progressive increase in the amplitude and duration of postsynaptic potentials, and stimulus-induced and spontaneous paroxysmal depolarization shifts (PDSs). Both the enhancement of synaptic transmission and the genesis of PDSs were reversibly blocked by the N-methyl-D-aspartate (NMDA) receptor antagonist (+/-)-2-amino-5-phosphonovalerate (APV). These results provide evidence that progressive, stimulation-induced long-term potentiation may serve as the trigger for kindling-induced epileptogenesis, and this process is dependent on the repeated activation of an APV-sensitive receptor. |
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Keywords: | hippocampus long-term potentiation kindling epilepsy guinea pig |
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