78例乳腺癌的nm23基因和ER表达及其临床意义

目的研究nm23和ER在乳腺癌组织中的表达及与转移的关系。方法采用免疫组化法（S—P法），对2000～2005年我科诊断的78乳腺癌患者的病理切片做回顾性分析。结果nm23、ER在无淋巴结转移的乳腺癌组阳性表达分别为84．4％、78．1％，明显高于有淋巴结转移的乳腺癌组（P〈0．01）。组织学分级中，分化程度越高，nm23、ER的阳性率越高（P〈0．01和P〈0．05）。结论乳腺癌的nm23和ER阳性表达率无淋巴结转移组明显高于有淋巴结转移组。nm23、ER阳性的乳腺癌分化较高，淋巴结转移发生较晚，预后较好。nm23和ER可作为判断乳腺癌预后的指标。

Expression and clincal signicance of nm23 gene and ER in 78 cases of breast carcinoma

Objective To study the relationship between the expression of nm23 and ER and the metastasis in the breast carcinoma tissue.Methods By adopting immunohistochemical(the method of S-P),to analyse and review pathologic cuts of 78 cases of breast carcinoma from 2000 to 2005 in our department.Results The percentage of the positive expression of nm23 and ER of breast carcinoma without lymphoid node metastasis was 84.4% and 78.1%.Obviously it was much higher than the percentage of breast carcinoma with lymphoid node metastasis(P<0.01).In histology grade,the higher differentiation degree was,the higher the positive rate of rim23 and ER was(P<0.01 and P<0.05).Conclusion The rate of the positive expression of nm23 and ER of breast carcinoma with out lymphoid node metastasis is much higher than that with lymphoid node metastasis.The differentiation degree of breast carcinoma with positive expression of nm23 and ER is higher,the lymphoid node metastasis occurs late and the prognosis is farourake.Nm23 and ER can be used as an index to judge the prognosis of breast carcinoma.