心缩间期测定在成人甲减患者中的应用

44例甲减病人分成三组:重度(9例)、轻度(28例)及亚临床组(7例),分别作STI测定。结果显示:44例甲减病人与对照组比较PEPI显著延长,LVETI显著缩短,PEP/LVET比值显著提高(P均为<0.001),重度组比轻度组STI改变更为显著,而亚临床组与对照组无显著差异;甲减病人T_4与LVETI呈正相关(P<0.01)与PEPI及PEP/LVET呈负相关。12例甲减病人经治疗后随甲状腺功能恢复STI转为正常。以上研究表明STI测定不仅反映甲减患者心功能状况,还能提示其甲状腺激素释放水平高低,并可作为评价甲减患者治疗效果的敏感指标。

DETERMINATION OF STI IN HYPOTHYROID PATIENTS

Systolic time intervals (STI) were used to evaluate myocardial function in 44 hypothyroid patients. The patients were divided into three groups according to lhe severity of disease :(Ⅰ) severe hypothyroidism (9 cases).(Ⅱ)mild hypothyroidism (28 cases) and (Ⅲ) subclinic status (7 cases). Results show that: All hypothyroid patients showed prolonged preejection period index (PEPI), shortened teft ventricular ejection time index (LVETI) and increase PEP/LVET(P<0.001, <0.001,<0.001 respectively) compared with normal controls; The STI were more abnormal in group Ⅰ than in groupⅡ, and grouq Ⅲ was not significantly different compared with controls; Positive correlation between T_4 and LVETI (p<0.01) and negative correlation between PEPI and PEP/LVET were shown in hypothyroid patients; Reversal of STI abnormalities follows upon clinically euthyroid in 12 patients after treatment with thyroid agent. The study indicated that determinations of STI reflect not only hypothyroid myocardial function but also suggest release level of thyroid hormone, Still STI which is a sensitive index may serve as to evaluate treatment effect on hypothyroid patients.