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Physical and genetic mapping of human chromosome 3 loci containing microsatellite repeats |
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| Authors: | Gerken Steve Whisenant Ethan Varkony Terry Todd Sean Gemmill Robert Jones Carol Weissenbach Jean Matsunami Norisada Moore Mary Lawrence Elizabeth White Ray Drabkin Harry A. |
| Affiliation: | (1) Division of Medical Oncology, B-171, University of Colorado Health Science Center, 4200 E. 9th Ave, 80262 Denver, CO, USA;(2) Eleanor Roosevelt Institute, Denver, CO, USA;(3) Department of Human Genetics, University of Salt Lake City, UT, USA;(4) Howard Hughes Medical Institute, Salt Lake City, UT, USA;(5) Genethon, 1 rue de l'Internationale, BP 59, 91002 Evry Cedex, France |
| Abstract: | One hundred and six microsatellite repeat-containing loci, including 59 CA-containing repeats from the CEPH/Genethon collection, were regionally assigned on human chromosome 3 using a somatic cell hybrid mapping panel, dividing the chromosome into 14 intervals. The others were dinucleotide and tetranucleotide repeat-containing loci newly developed for human chromosome 3, of which 26 were also localized by means of genetic linkage analysis against selected CEPH microsatellites. The regional assignment of these two marker sets in a common mapping panel facilitates their integration. Incorporation of these highly polymorphic loci into the developing physical and genetic maps should provide useful information for studies of various diseases involving chromosome 3. |
| Keywords: | human chromosome 3 genetic mapping linkage microsatellite repeats physical mapping |
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