Disseminated intravascular coagulation associated with toxic epidermal necrolysis (Lyell''s syndrome) |
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| Authors: | JAN KAVASNI&# KA,JAN &# EZÁ &# ,&dagger ,JI&# Í &# VEJDA,&Dagger ,HANA DUCHKOVÁ ,§ ,FRANTI&# EK KAZE,PAVEL &# ALUD&dagger ,JOSEF RICHTER |
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| Affiliation: | Departments of Haematology, Regional Hospital, Usti had Labem, Czechoslovakia;Departments of Anaesthesiology, Regional Hospital, Usti had Labem, Czechoslovakia;Departments of Infectious Diseases, Regional Hospital, Usti had Labem, Czechoslovakia;Departments of Dermatology, Regional Hospital, Usti had Labem, Czechoslovakia;Departments of Immunology, Regional Hospital, Usti had Labem, Czechoslovakia |
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| Abstract: | Evidence of disseminated intravascular coagulation was recorded in eight patients with toxic epidermal necrolysis (TEN)--Lyell's syndrome. Patients were treated with low doses of heparin in combination with the usual treatment of TEN, i.e. maintenance of fluid and electrolyte balance, systemic corticosteroids, antibiotics and aseptic dressings, in the Intensive Care Unit environment. It is suggested that the alteration of haemostasis and inter-related biological systems, such as activation of components of complement, kinins and immunoglobulins, may affect the outcome of TEN. |
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