拉米夫定联合维生素E治疗慢性乙型肝炎临床观察

目的探讨拉米夫定联合维生素E对慢性乙型肝炎患者的治疗效果。方法将120例慢性乙型肝炎患者随机分为对照组和治疗组,对照组给予拉米夫定,治疗组在对照组基础上加用维生素E,疗程6个月,比较两组治疗前后ALT、HBV DNA及HBsAg、HBeAg、HBeAb的变化。结果慢性乙型肝炎治疗组的ALT复常率、HBV DNA的转阴率与HBeAg的阴转率及HBeAb的阳转率均较对照组明显增高(P＜0．05)。结论维生素E可作为治疗慢性乙型肝炎的辅助药物。

Study on the antiviral outcome of lamivudine combined with Vit E in the patients with chronic hepatitis B

Objective To evaluate the antiviral outcome of lamivudine combined with Vitamin E in the patients with chronic hepatitis B.Methods One hundred and twenty patients with chronic hepatitis B were classified into the control group and Vitamin E group randomly.All the patients included in the control group were given oral lamivuding with the dose of 100mg daily for six months.Meanwhile,the other subjects were given additional Vitamin E with the dose of 01g thricely a day.Results At the end of the study period,alanine aminotransferase(ALT)normalization was observed in 54(90%)patients in Vitamin E group and only in 45(75%)of the controls(P＜0.01);HBV-DNA negative conversion was observed in 48(80%)patients in the Vitamin E group as compared to 38(63.3%)in the control group, respectively(P＜0.01).Compared with the 4(6.7%)in the controls,the serum negative conversion of HBeAg was found in 12(20%)patients in the Vitamin E group.Conclusion Vitamin E supplementation might be effective in the treatment of chronic hepatitis B.