| 胰岛素样生长因子-Ⅰ对早期胚胎发育终止的影响 |
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| 引用本文： | 于月成,辛晓燕,白晓霞,王德堂,郭会玲.胰岛素样生长因子-Ⅰ对早期胚胎发育终止的影响[J].现代妇产科进展,2003,12(6):426-428. |
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| 作者姓名： | 于月成 辛晓燕 白晓霞 王德堂 郭会玲 |
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| 作者单位： | 1. 第四军医大学西京医院妇产科,西安,710032
2. 解放军第88医院 |
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| 摘 要： | 目的 :探讨胰岛素样生长因子 Ⅰ (IGF I)在早期胚胎发育终止绒毛中的表达以及母体血中IGF I水平改变与胚胎发育终止的关系。方法 :采用免疫组化法 (SP法 )检测早期胚胎发育终止绒毛中IGF I蛋白的表达 ,采用原位杂交法 (ISH)检测IGF ImRNA的表达 ,以正常妊娠为对照组。采用酶联免疫吸附试验 (ELISA)检测正常妊娠及早期胚胎发育终止孕妇血中IGF I水平的变化。结果 :正常妊娠绒毛中IGF I、IGF ImRNA的表达均明显高于胚胎发育终止组 (P <0 .0 1) ;正常妊娠组母血中IGF I水平显著高于胚胎发育终止组 (P <0 .0 1)。结论 :IGF I在绒毛组织中的表达及母血中的水平与胚胎发育密切相关 ,其含量减少可能是导致胚胎死亡的重要原因之一
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| 关 键 词： | 胰岛素样生长因子-I 早期妊娠 胚胎发育终止 绒毛 |
| 文章编号： | 1004-7379(2003)06-0426-03 |
| 修稿时间： | 2003年5月26日 |
Relationship of villus and serum insulin-like growth factor-Ⅰ and embryogenesis termination of early pregnancy |
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| Yu Yuecheng ,Xin Xiaoyan ,Bai Xiaoxia ,et al..Relationship of villus and serum insulin-like growth factor-Ⅰ and embryogenesis termination of early pregnancy[J].Current Advances In Obstetrics and Gynecology,2003,12(6):426-428. |
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| Authors: | Yu Yuecheng Xin Xiaoyan Bai Xiaoxia |
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| Institution: | Yu Yuecheng 1,Xin Xiaoyan 1,Bai Xiaoxia 2,et al.1.Department of Obstetrics and Gynecology,Xijing Hospital,the Fourth Military Medical University,Xi'an 710032,2.No.88 Hospital of PLA |
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| Abstract: | Objective:To investigate the relationship of villus expression and serum level of insulin like growth factor I (IGF I) and embryogenesis termination of early pregnancy.Methods:Expression of IGF I was measured by immunohistochemistry.The expression of IGF I mRNA was detected by in situ hybridization(ISH).Serum IGF I level was determined by enzyme linked immunoabsorbent assay (ELISA).Results:Both the expressions of IGF I protein and mRNA were lower in the abnormal villus of embryogenesis termination than that of normal villus(P<0.01).Serum level of IGF I in normal pregnancy women was much higher than that of abnormal pregnancy women.Conclusion:IGF I may play an important role in the regulation of fetal growth.Decrease of IGF I either in villus or in serum may be one of the key factors contributing to the embryogenesis termination of early pregnancy. |
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| Keywords: | Insulin like growth factor I Pregnancy trimester first Embryogenesis termination Villus |
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