| RP-HPLC法测定止咳祛痰颗粒中盐酸麻黄碱的含量 |
| |
| 引用本文： | 廖新麟. RP-HPLC法测定止咳祛痰颗粒中盐酸麻黄碱的含量[J]. 中国药师, 2010, 13(2): 237-238 |
| |
| 作者姓名： | 廖新麟 |
| |
| 作者单位： | 南宁食品药品检验所,南宁,530001 |
| |
| 摘 要： | 目的：建立反相高效液相色谱法测定止咳祛痰颗粒中盐酸麻黄碱的含量。方法：色谱柱：BondpackC18（250mm×4．6mm，5μm），流动相：乙腈02mol·L-1磷酸二氢钠溶液（用磷酸调节pH2．7）（5：100），检测波长：210nm。结果：盐酸麻黄碱进样量在0．160—1．600μg范围内，其浓度与峰面积呈良好的线性关系（r=0．9999），平均回收率为99．76％（RSD=0．54％）。结论：该方法能消除其他成分的干扰，准确可靠，重复性好，操作简便快捷，可用于该制剂的质量控制。
|
| 关 键 词： | 盐酸麻黄碱 止咳祛痰颗粒 反相高效液相色谱法 |
Determination of Ephedrine Hydrochloride in Zhike Qutan Granules by RP-HPLC |
| |
| Liao Xindin. Determination of Ephedrine Hydrochloride in Zhike Qutan Granules by RP-HPLC[J]. China Pharmacist, 2010, 13(2): 237-238 |
| |
| Authors: | Liao Xindin |
| |
| Affiliation: | Liao Xinlin (Nanning Institute for Food and Drug Control ,Nanning 530001, China) |
| |
| Abstract: | Objective： To establish a determining method for ephedrine hydrochloride in zhike qutan granules by HPLC. Method： Agilent C18 （250 mm × 4. 6 mm ,5 μm） was used as stationary phase, acetonitrile-0. 02 mol. L-1 sodium di-hydrogen phosphate （pH val- ue adjusted to 2. 7 with phosphoric acid） （ 5： 100） was as mobile phase,the wavelength of detection was at 210 nm. Result： The cali- bration curve was showed good linearity （r = 0. 999 9） within the range of 0. 160-1. 600 μg, the average recovery was 99. 76% with. RSD = 0.54%. Conclusion： The interference of other components can be ehminated by this method, which is accurate, precise and simple and can be availble for the quality control of the zhike qutan granules. |
| |
| Keywords: | Ephedrine Hydrochloride Zhike qutan granules RP- HPLC |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
