| 血清组织蛋白酶S、胱抑素C水平与冠状动脉粥样硬化病变严重程度相关性的研究——附107例报告 |
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| 引用本文： | 刘玉胜,鹿庆华,蒋卫东,杜贻盟,王永梅,张华岩,王欣,徐冬玲,郝琳,盛林,王群,秦爱琼. 血清组织蛋白酶S、胱抑素C水平与冠状动脉粥样硬化病变严重程度相关性的研究——附107例报告[J]. 新医学, 2008, 39(4): 219-221 |
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| 作者姓名： | 刘玉胜 鹿庆华 蒋卫东 杜贻盟 王永梅 张华岩 王欣 徐冬玲 郝琳 盛林 王群 秦爱琼 |
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| 作者单位： | 山东大学第二医院心内科,250033 |
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| 基金项目： | 山东省自然科学基金，山东省中医管理局资助项目 |
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| 摘 要： | 目的:探讨冠状动脉粥样硬化性心脏病(冠心病)患者血清组织蛋白酶S(cathepsin S,CatS)及胱抑素C水平与冠状动脉病变程度的关系.方法:对155例疑诊心绞痛患者进行冠状动脉造影(coronary angiography,CAG),根据GAG结果分为冠心病组(107例)及对照组(48例),测定所有入选者的空腹血清CatS、胱抑素C水平,采用Gensini积分对冠状动脉病变程度进行评价并分析它们之间的关系.结果:冠心病组血清CatS、胱抑素C水平较对照组高(P＜0.01),前者上升幅度更大,血清CatS水平与Gensini积分呈正相关(r=0.69,P＜0.01),Logistic回归分析剔除年龄、性别、收缩压、血清总胆固醇等因素后,此相关性仍存在(r=0.71,P＜0.01).结论:冠心痛患者的血清CatS、胱抑素C的水平增高,且CatS与冠状动脉粥样硬化病变程度密切相关,说明CatS及胱抑素C可能参与细胞外基质重塑的过程.
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| 关 键 词： | 组织蛋白酶S 胱抑素C 冠状动脉病变 Gensini积分 相关性 |
| 修稿时间： | 2007-12-10 |
Correlation between serum levels of cathepsin S and cystatin C and the severity of atherosclerostic lesions of coronary arteries |
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| Liu Yusheng,Lu Qinghua,Jiang Weidong,et al.. Correlation between serum levels of cathepsin S and cystatin C and the severity of atherosclerostic lesions of coronary arteries[J]. New Chinese Medicine, 2008, 39(4): 219-221 |
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| Authors: | Liu Yusheng Lu Qinghua Jiang Weidong et al. |
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| Affiliation: | Liu Yusheng,Lu Qinghua,Jiang Weidong,et al.The Department of Cardiology,The Second Hospital of Sh,ong University,Ji'nan,250033,China |
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| Abstract: | Objective:To investigate the correlation between serum levels of cathepsin S and cystatin C and the severity of atherosclerostic lesions of coronary arteries.Methods:155 patients were undertaken coronary angiography and divided into the coronary artery disease group(n=107)and the control group(n=48)according to the result.Fasting total serum concentrations of cathepsin S and cystatin C were measured and the severity of lesions of coronary arteries were assessed and analyzed by Gensini score in all patients.... |
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| Keywords: | Cathepsin S Cystatin C Lesions of coronary arteries Gensini score Correlation |
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