| 缺血预处理对离体大鼠心脏缺血再灌注的保护作用 |
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| 引用本文： | 何洁. 缺血预处理对离体大鼠心脏缺血再灌注的保护作用[J]. 昆明医学院学报, 2000, 21(3): 7-10 |
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| 作者姓名： | 何洁 |
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| 作者单位： | 昆明医学院病理生理教研室,昆明,650031 |
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| 基金项目： | 国家自然科学基金资助项目 !( 3 9670 3 0 8) |
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| 摘 要： | 应用Ｌａｎｇｅｎｄｏｒｆｆ灌流模型，研究离体大鼠心肌缺血预处理（ＩＰＣ）对心脏缺血再灌注时心功能指标及乳酸脱氢酶（ＬＤＨ）和丙二醛（ＭＤＡ）含量的影响。结果：ＩＰＣ可使缺血再灌期心肌收缩和舒张性能显著改善，心肌细胞受损明显减轻，心肌ＭＤＡ含量也明显降低。结果表明：ＩＰＣ对心肌缺血再灌注损伤有良好的保护作用，而减轻氧自由基对细胞的损伤作用可能是其保护机制之一。
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| 关 键 词： | 缺血预处理 再灌注损伤 心肌缺血 大鼠 LDH MDA |
The Protective Effect of Ischemic Preconditioning against Ischemia and Reperfusion Injury in Rat Heart |
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| HE Jie. The Protective Effect of Ischemic Preconditioning against Ischemia and Reperfusion Injury in Rat Heart[J]. Journal of Kunming Medical College, 2000, 21(3): 7-10 |
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| Authors: | HE Jie |
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| Abstract: | The effect of ischemic preconditioning on the cardiac functions, and the LDH and MDA levels of isolated rat heart during the ischemia and reperfusion were observed in the present study by using the Langendorff model. It showed that the ischemic preconditioning might promote the recovery of myocardial contractile and diastolic functions and the decrease in the LDH and MDA levels. The results indicated that the ischemic preconditioning could possess protective effect for rat myocardium during the ischmia and reperfusion injury. The mechanism might be due to a decrease in the effect of oxygen free radicals. |
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| Keywords: | Ischemic preconditioning Myocardium Reperfusion Malondialdehyde |
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