| 乙酰肝素酶与肿瘤转移研究进展 |
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| 引用本文： | 彭大颖,高志安. 乙酰肝素酶与肿瘤转移研究进展[J]. 中国全科医学, 2007, 10(7): 583-585 |
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| 作者姓名： | 彭大颖 高志安 |
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| 作者单位： | 121000,辽宁医学院附属第一医院病理科 |
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| 摘 要： | 乙酰肝素酶（heparanase，HPA）是一种葡萄糖醛酸内切酶，它既存在于正常组织，如胎盘和淋巴器官，对胚胎形成，神经系统发育，新生血管形成，炎症反应发挥着正常的生理功能；也表达于多种恶性肿瘤细胞，促进细胞侵袭和转移，诱导肿瘤血管生成。HPA抑制剂的研究可望为抗肿瘤治疗开辟新的途径。
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| 关 键 词： | 乙酰肝素酶 硫酸乙酰肝素糖蛋白 肿瘤 血管生成 肿瘤转移 |
| 文章编号： | 1007-9572(2007)07-0583-03 |
| 修稿时间： | 2007-02-02 |
Advance in Research of Heparinase in Tumor Metastasis |
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| PENG Da-ying,GAO Zhi-an. Advance in Research of Heparinase in Tumor Metastasis[J]. Chinese General Practice, 2007, 10(7): 583-585 |
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| Authors: | PENG Da-ying GAO Zhi-an |
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| Affiliation: | Institute of Pathology,Medical College of Liaoning University, Jinzhou 121000, China |
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| Abstract: | Heparinase is a kind of endoglycosidases. It exists not only in normal tissues such as placenta and lymph organ, but also in a variety of tumor cells. It plays an important role in embryo formation, nervous system development, anglogenesis and inflammation reaction, as well as in invasion and metastasis of tumor Cells and inducing angiogenesis of tumor, It is expected that the study of heparinase inhibitor may open a new way for antineoplastic treatment, |
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| Keywords: | Heparanase Heparan sulfate proteohoycan Tumor Angiogenesis Metastasis |
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