癫痫患者血浆激素水平变化的研究

目的：（1）了解癫痫患者的血浆激素水平变化情况；（2）服抗癫痫药物（ami-epilepsy drugs，AEDs）对于癫痫患者血浆激素水平的影响。方法：用电化学发光法检测人组癫痫患者的泌乳素（prolactin，PRL）、雌二醇（estradiol，E2）、孕酮（progesterone，PG）以及总睾酮（totol testosterone，TTes）的血浆水平，并分别比较男、女患者未用抗癫痫药物组（NAEDs组）与用药组（AEDs组）的血浆激素水平的变化。结果：（1）人组71例患者，男性32例，女性39例；50．70％（36／71）有PRL水平升高，43．66％（35／71）患者E2水平升高，分别有18．31％（13／71）和25．35％（18／71）患者的TYes、PG水平下降。（2）女性癫痫患者中，AEDs组患者有77．78％（21／27）出现E2升高，NAEDs组为41．67％（5／12），两组有显著差异，P〈0．05；男性癫痫患者中，AEDs组33．33％（5／15）出现TTes水平下降，NAEDs组为5.90％（1／17），两组有显著差异。结论：（1）癫痫患者的激素水平有变化；（2）抗癫痫药物可影响激素水平。男女患者的激素受抗癫痫药物的影响变化不同，男性患者的TYes水平降低，女性患者的E2水平升高可能与抗癫痫药物的应用有关。

The Study of the Serum Hormone Concentration Changes in Patients with Epilepsy

Objective: 1. To investigate the serum hormone concentrations changes in patients with epilepsy, 2. To evaluate serum hormone changes of the anti-epileptic drugs effects. Methods: All the participants were drawn blood sample for the analysis of serum prolactin (PRL), estradiol (E2), progesterone( PG) and Totol testosterone( TTes ). Results: 1. The study was performed in 71 epileptic patients (male 32 female 39). The levels of PRL and E2 were high in most patients, the radio was 50. 70%(36/71) and 43. 66%(35/71) respectively. The concentrations of PG and TTes were reduced in 18(25. 35% ,18/71)patients and 13(18. 31% ,13/71)patients. 2. The incidence of elevation of serum E2concentration was 77. 78% in women patients with anti-epilepitic drug, meanwhile,41. 67% in those without the treatment, which showed significant differences. TTes were low in 5(33. 33%) men patients with the antiseizure treatment, it is 5. 90%(1/17) in patients without treatment, the difference is significant. The varies of PG and PRL between the patients with or without medical treatment showed no differences. Conclusions ;1)There were changes of the serum hormone concentration in patients with epilepsy. 2)Antiepilep-tic drug affected the serum hormone concentrations.