近3年重症监护病房细菌耐药分析

目的了解重症监护病房(ICU)院内感染的流行病学及细菌耐药性变化情况.方法对本院ICU 2001年1月～2003年12月的所有分离菌株进行分析.结果共分离222株细菌,革兰阴性(G-)杆菌共127株(57.21%).革兰阳性(G )菌43株(19.36%).G-杆菌前3位是大肠埃希菌、铜绿假单胞菌、沙雷菌.G 球菌前3位分别是表皮葡萄球菌、金黄色葡萄球菌、粪肠球菌.对第三代头孢菌素耐药率较高,对亚胺培南、万古霉素保持较高的敏感性.结论ICU感染的细菌仍以G-杆菌为主,G 菌感染有上升趋势.细菌耐药率高.应根据细菌耐药监测,指导临床用药,以控制耐药菌的产生.

Analysis of bacterial drug resistance of nosocomial infection in ICU

Aim To investigate the common pathogens of nosocomial infection and bacterial resistance profile in a general intensive care unit ( ICU ). Methods We analyzed all the bacterial isolates in the ICU of third hospital of Bengbu from 2001 to 2003. ResultsAmong 222 clinical isolates, gram-positive organisms accounted for 19.36 % , gram-negative organisms 57.21 %. The most common isolates of gram-positive bacilli was staphylococcus epidemidis ,then S aureus and E fecalis , in gram-negative bacilli they were E. coli , pseudomonas aeruginosa and Serratia marceseans. All the organisms exhibited a high sensitivity to vancomycin and Imipenem but a high resistance to third generation cephalosporins. Conclusion The most prevalent pathogens of nosocomial infection in ICU were still gram-negative bacilli. Gram-positive rods became important pathogens of nosocomial infection. Most pathogens showed significant resistance to the most commonly antibiotics. In order to control nosocomial infection , it is necessary to direct the choice of antibiotics by monitoring the resistance to antibiotics.