金属硫因蛋白在涎腺肿瘤中的表达及意义

为了研究金属硫因蛋白在涎腺肿瘤中的表达特点，作者用免疫组织化学方法对７５例涎腺肿瘤进行了研究。在腺上皮和肌上皮混合构成的肿瘤，如：腺样囊性癌、多形性腺瘤、腺上皮肌上皮癌、基底细胞腺瘤（癌）等，金属硫因蛋白只在肌上皮细胞中表达并且均有较强染色。肌上皮癌和肌上皮瘤中有相当多的细胞表达金属硫因蛋白。抗金属硫因蛋白单克隆抗体对肌上皮细胞的染色在部分病例较Ｓ－１００蛋白和平滑肌动蛋白效果好。本结果表明，金属硫因蛋白可能成为涎腺肿瘤性肌上皮细胞较好的标志，有助于涎腺肿瘤的鉴别诊断。

Metallothionein expression and its significance in salivary gland tumors

Expression of metallothionein (MT) in 75 cases of salivary gland tumors was studied by immunohistochemistry. All tumors containing myoepithelial cells were positive for MT immunostaining. In the tumors composed of both adenoepithelial cells and myoepithelial cells, only myoepithelial cells were MT positive. A rather large portion of cells was noted MT positive in myoepithelial carcinoma and myoepithelioma. Compared with S 100 and smooth muscle actin (SMA) antibodies, the effect of staining by MT antibody for myoepithelial cells was more satisfactory. The results indicate that MT may be a better marker for neoplastic myoepithelial cells and useful in the differential diagnosis of salivary gland tumors.