Hormonally Functional Ovarian Neoplasms |
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Authors: | Roth Lawrence M Billings Steven D |
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Institution: | (1) Department of Pathology, Indiana University Hospital, Room 3465, 550 North University Boulevard, 46202-5280 Indianapolis, IN |
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Abstract: | Hormonally functional ovarian neoplasms are those tumors that secrete one or more hormones that are clinically manifested
in the patient. The hormone production may have implications for the diagnosis, management, or treatment of the patient. Hormonally
functional ovarian neoplasms include tumors that belong to various histologic categories and produce a variety of hormonal
effects. Functional ovarian tumors most commonly produce steroid hormones, and such tumors frequently belong in the sec cordstromal
and steroid cell categories. In addition, a wide variety of peptide hormones may be produced by ovarian tumors. Although in
most instances the neoplastic cells themselves produce the hormones, a wide variety of tumors may induce their stroma to produce
steroid hormones. The stroma of ovarian tumors is derived from the ovarian stroma and may, on occasion, resemble specialized
ovarian stroma and its derivatives. Cells resembling luteinized stromal cells or luteinized theca cells may be present and
appear to be responsible for the resultant hormone secretion. |
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Keywords: | Ovarian neoplasms pathology functional hormonal |
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