| 阻塞性睡眠呼吸暂停患者白细胞抗原分型 |
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| 引用本文： | 肖丹,康健,胡雪君,王秋月,侯显明,于润江.阻塞性睡眠呼吸暂停患者白细胞抗原分型[J].中国公共卫生,2003,19(8):926-927. |
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| 作者姓名： | 肖丹 康健 胡雪君 王秋月 侯显明 于润江 |
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| 作者单位： | 1. 首都医科大学附属北京天坛医院呼吸科,北京,100050
2. 中国医科大学呼吸疾病研究所 |
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| 摘 要： | 目的 明确遗传因素在阻塞性睡眠呼吸暂停(OSA)患发病上的作用。方法 以中国北方35例OSAS患作为研究对象，北方汉族健康人群作为对照，采用聚合酶链反应．序列特异引物(PCR-SSP)分析的方法分析HLA-A，-B，-DR抗原。结果 OSAS患HLA-A2，-B15，-DRB1*02，-DRBI*07及-DRBI*12抗原频率较对照组明显增高。结论 OSAS患发病与HLA抗原特异性有关。
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| 关 键 词： | 睡眠无呼吸综合征 人类白细胞抗原 遗传 |
| 文章编号： | 1001-0580(2003)08-0926-02 |
| 修稿时间： | 2003年3月20日 |
Study on leukocyte antigen(HLA) type of patients with obstructive sleep apnea |
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| XIAO Dan,KANG Jian,HU Xue-jun,et al..Study on leukocyte antigen(HLA) type of patients with obstructive sleep apnea[J].Chinese Journal of Public Health,2003,19(8):926-927. |
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| Authors: | XIAO Dan KANG Jian HU Xue-jun |
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| Institution: | XIAO Dan,KANG Jian,HU Xue-jun,et al.Institute of Respiratory Disease,China Medical University |
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| Abstract: | Objective To investigate the possible genetical influence on subjects with obstructive sleep spnea syndrome(OSAS). Methods Polymerase chain reaction-sequence specific primer(PCR-SSP)technique was used to analyse HLA-A, -B ,-DR antigens of 35 patients living in northern mandarine and with OSAS diagnosed by whole-night PSG. Results The frequency of HLA-A2,-B15,-DRB1*02,-DRB1*07,-DRB1*12 antigens were markedly increased in patients with OSAS compared with those in general population in northern China. Conclusion The specific HLA antigens might be relevant to the development of OSAS in patients living in northern mandarin China. |
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| Keywords: | sleep apnea syndrome human leunkocyte antigen heredity |
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