| ω-3多不饱和脂肪酸改善老年痴呆症动物模型病理的研究 |
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| 引用本文： | 胡为民,符明. ω-3多不饱和脂肪酸改善老年痴呆症动物模型病理的研究[J]. 临床医药实践, 2003, 12(12): 891-892 |
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| 作者姓名： | 胡为民 符明 |
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| 作者单位： | 1. 山西医科大学第二医院,山西,太原,030001
2. 加州大学洛杉矶分校医学院,美国,洛杉矶,91343 |
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| 摘 要： | 目的 :探讨ω-3多不饱和脂肪酸二十二碳烯酸 (DHA)对老年痴呆症 (AD)转基因小鼠模型病理改变的影响。方法 :给 AD转基因小鼠从 17个月～ 2 2个月期间喂饲普通饲料 ,无 DHA及高 DHA饲料。检测其β-淀粉样肽(Aβ)水平及突触后致密结构组分 (PSD-95)含量变化。结果 :Aβ水平在高 DHA组下降达 60 % ,而 PSD-95在无 DHA组和对照组明显下降 ,差异显者 ,P<0 .0 1。结论 :富含 DHA的饲料可以减少 Aβ在 AD动物模型脑内的沉积 ,并对突触结构具有保护作用
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| 关 键 词： | 老年痴呆症 二十二碳六烯酸 β-淀粉样肽 突触后致密结构 |
| 文章编号： | 1671-8631(2003)12-0891-02 |
| 修稿时间： | 2003-11-05 |
The study of ω-3 polyunsaturaed acid on pathology in mouse models of alzheimers disease |
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| HU Wei min ,FU Ming. The study of ω-3 polyunsaturaed acid on pathology in mouse models of alzheimers disease[J]. Proceeding of Clinical Medicine, 2003, 12(12): 891-892 |
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| Authors: | HU Wei min FU Ming |
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| Affiliation: | HU Wei min 1,FU Ming 2 |
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| Abstract: | Objective:To investigate the effects of ω 3 polyunsaturated acid docosahexaenoic acid(DHA)on pathology in mouse models of alzheimers disease.Methods:Seventeen month old animals were placed in one of three groups:standard diets(0.09 %DHA),diets with no DHA and diets enrichd with 0.6 % DHA.Animals were treated until 22 monchs of age and measurements of Aβ and PSD 95 were made in the cortex.Results:Aβ was significantly reduced by 60 % in mice fed DHA enriched diet compared to mice on DHA depleted diet.PDS 95 was significantly reduced in mice fed diets with no DHA and control.Conclusions:These results may suggest that a diet containing DHA could be protective against Aβ accumulation and synaptic degeneration. |
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| Keywords: | alzheimer′s disease docosahexaenoic acid beta amyloid post synaptic density |
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