| 黄芪保心汤治疗冠心病心绞痛的临床观察 |
| |
| 引用本文： | 李广浩,徐雯婷,曹敏,王佑华,周端,沈琳,赵慧,杨爱玲,樊华,彭珑萍. 黄芪保心汤治疗冠心病心绞痛的临床观察[J]. 上海中医药大学学报, 2019, 33(1): 20-23, 41 |
| |
| 作者姓名： | 李广浩 徐雯婷 曹敏 王佑华 周端 沈琳 赵慧 杨爱玲 樊华 彭珑萍 |
| |
| 作者单位： | 上海中医药大学附属龙华医院心内科;上海中医药大学附属龙华医院急诊科 |
| |
| 基金项目： | 第六批全国老中医药专家学术经验继承工作项目(国中医药人教发2017)；上海中医药大学中西医结合高原学科面上项目；上海中医药大学附属龙华医院爱建捐赠基金项目(AJ018) |
| |
| 摘 要： | 目的:观察黄芪保心汤治疗冠心病心绞痛的临床疗效,并探讨其相关作用机制。方法:纳入痰瘀互结证冠心病心绞痛患者126例,随机分为治疗组和对照组,每组各63例。对照组患者给予西医常规治疗,治疗组患者在西医常规治疗基础上加服黄芪保心汤,两组治疗周期均为8周。评价两组患者的中医证候疗效;检测患者的血浆黏度、红细胞压积、全血低切黏度、全血高切黏度、纤维蛋白原(Fg)等血液流变学指标,检测天冬氨酸氨基转移酶(AST)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)及血浆内皮素(ET)、血栓素B2(TXB2)、前列腺素F1α(PGF1α)水平。结果:治疗后,治疗组的中医证候疗效总有效率为90.48%,对照组为84.13%,治疗组疗效优于对照组(P0.05)。治疗后,治疗组患者的血浆黏度、红细胞压积、全血低切黏度、全血高切黏度、Fg水平均明显降低(P0.05,P0.01),对照组患者的全血低切黏度、Fg水平亦明显降低(P0.05,P0.01),且治疗组患者的血浆黏度、全血低切黏度、全血高切黏度水平低于对照组(P0.01)。治疗后,两组患者的CK-MB、CK、LDH水平均显著降低(P0.05,P0.01),治疗组患者的AST水平亦降低(P0.01),且治疗组患者的CK-MB、CK、LDH、AST水平低于对照组(P0.05,P0.01);治疗后,两组患者的TXB2、ET水平均显著降低(P0.01),PGF1α水平升高(P0.01),且治疗组患者的TXB2、ET水平低于对照组(P0.05),PGF1α水平高于对照组(P0.01)。结论:黄芪保心汤结合西医常规疗法治疗痰瘀互结证冠心病心绞痛患者,能够较好改善患者的中医证候,降低患者的心肌酶水平,减轻心肌细胞损伤,其作用机制可能与改善患者的血液流变学,提高血浆PGF1α及降低TXB2、ET水平有关。
|
| 关 键 词： | 冠心病 心绞痛 黄芪保心汤 中西医结合 |
| 收稿时间： | 2018-09-20 |
| 修稿时间： | 2018-12-08 |
Clinical observation of Huangqi Baoxin Decoction in treating patients with coronary heart disease and angina pectoris |
| |
| LI Guanghao,XU Wenting,CAO Min,WANG Youhu,ZHOU Duan,SHEN Lin,ZHAO Hui,YANG Ailing,FAN Hua and PENG Longping. Clinical observation of Huangqi Baoxin Decoction in treating patients with coronary heart disease and angina pectoris[J]. Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai, 2019, 33(1): 20-23, 41 |
| |
| Authors: | LI Guanghao XU Wenting CAO Min WANG Youhu ZHOU Duan SHEN Lin ZHAO Hui YANG Ailing FAN Hua PENG Longping |
| |
| Affiliation: | Department of Cardiology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China,Department of Emergency, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China,Department of Emergency, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China,Department of Cardiology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China,Department of Cardiology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China,Department of Cardiology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China,Department of Cardiology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China,Department of Cardiology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China,Department of Cardiology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China and Department of Cardiology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China |
| |
| Abstract: | |
| |
| Keywords: | coronary heart disease angina pectoris Huangqi Baoxin Decoction integrated Chinese and western medicine |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《上海中医药大学学报》浏览原始摘要信息 |
|
点击此处可从《上海中医药大学学报》下载免费的PDF全文 |
|
