| TSLP基因多态性与婴幼儿特应性皮炎相关性研究 |
| |
| 引用本文： | 唐琳,朱晨琛,肖烨,魏冰,蔡眉,张晓璟,唐振华.TSLP基因多态性与婴幼儿特应性皮炎相关性研究[J].检验医学,2019(3):249-252. |
| |
| 作者姓名： | 唐琳 朱晨琛 肖烨 魏冰 蔡眉 张晓璟 唐振华 |
| |
| 作者单位： | 上海交通大学医学院附属国际和平妇幼保健院上海市胚胎源性疾病重点实验室 |
| |
| 摘 要： | 目的探讨新生儿脐血胸腺基质淋巴细胞生成素(TSLP)基因多态性与婴幼儿特应性皮炎(AD)的关系。方法选取足月分娩孕妇393例,提取其脐血基因组DNA,采用聚合酶链反应(PCR)-高温连接酶反应(LDR)检测TSLP基因rs3806933、rs1545169、rs764917、 rs1837253、rs2289276和rs11466749位点的基因型。有285例新生儿在其2岁时通过电话回访明确其出生后有无医生确诊的AD(诊断AD 162例)。结果新生儿脐血TSLP基因rs3806933、rs1545169、rs764917、 rs1837253和rs2289276位点基因型分布频率在无AD组和有AD组间无明显差异(P>0.05)。rs11466749位点基因型(AA/AG)分布频率在AD组与无AD组间有明显差异(AD组rs11466749位点AA型占60.0%,AG型占34.3%;无AD组rs11466749位点AA型占40.0%,AG型占65.7%。结论新生儿脐血TSLP基因rs11466749基因多态性与其2岁内AD有一定相关性。
|
| 关 键 词： | 特应性皮炎 基因多态性 脐血 |
Correlation between TSLP gene polymorphism and toddler atopic dermatitis |
| |
| TANG Lin,ZHU Chenchen,XIAO Ye,WEI Bing,CAI Mei,ZHANG Xiaojing,TANG Zhenhua.Correlation between TSLP gene polymorphism and toddler atopic dermatitis[J].Laboratory Medicine,2019(3):249-252. |
| |
| Authors: | TANG Lin ZHU Chenchen XIAO Ye WEI Bing CAI Mei ZHANG Xiaojing TANG Zhenhua |
| |
| Institution: | (Shanghai Key Laboratory of Embryo Original Diseases,the International Peace Maternity and Child Health Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200030,China) |
| |
| Abstract: | TANG Lin;ZHU Chenchen;XIAO Ye;WEI Bing;CAI Mei;ZHANG Xiaojing;TANG Zhenhua(Shanghai Key Laboratory of Embryo Original Diseases,the International Peace Maternity and Child Health Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200030,China) |
| |
| Keywords: | Atopic dermatitis Gene polymorphism Cord blood |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
