| 城市大气可吸入颗粒物对大鼠变应性鼻炎模型发病的影响 |
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| 引用本文： | Xing Z,Liu X,Yu L,Wang M. 城市大气可吸入颗粒物对大鼠变应性鼻炎模型发病的影响[J]. 临床耳鼻咽喉头颈外科杂志, 2011, 25(11): 506-509 |
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| 作者姓名： | Xing Z Liu X Yu L Wang M |
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| 作者单位： | 北京大学人民医院耳鼻咽喉科,北京,100044 |
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| 基金项目： | 科技部十一五科技支撑计划课题"变应性鼻炎规范化诊断和防治体系的研究" |
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| 摘 要： | 目的:探讨大气可吸入颗粒物(PM10)在激发大鼠变应性鼻炎过程中所起的作用及其可能的机制.方法:使用卵清蛋白(OVA)给予大鼠腹腔注射予以基础致敏,致敏结束后3个实验组分别用单独OVA、PM10+OVA联合及单独PM10鼻腔滴入予以激发,对照组用生理盐水代替OVA致敏,生理盐水激发,方法同实验组.观察并记录各组大鼠在激发过程中变应性鼻炎的症状,末次激发后24 h处死大鼠,取鼻黏膜行免疫组织化学染色检测IL-4的表达情况.结果:OVA组和PM10+OVA组均诱发出明显的变应性鼻炎症状,而PM10组和对照组偶有搔鼻症状;症状积分PM10+OVA组与OVA组比较差异具有统计学意义(P＜0.01),并分别与对照组比较差异均有统计学意义(均P＜0.01);PM10组与对照组比较差异无统计学意义(P＞0.05).IL-4阳性表达的细胞计数3个实验组与对照组比较差异均有统计学意义(P＜0.01),3个实验组之间比较存在显著性差异,PM10+OVA组明显高于OVA组(P<0.01).结论:PM10在激发大鼠变应性鼻炎的过程中与变应原共同作用可以增强变应性炎症反应,加重大鼠变应性鼻炎的症状.
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| 关 键 词： | 鼻炎,变应性 常年性 可吸入颗粒物 SD大鼠 白细胞介素-4 |
Experimental study on the impact of urban inhalable particles on allergic rhinitis of rats |
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| Xing Zhimin,Liu Xiaoling,Yu Lisheng,Wang Min. Experimental study on the impact of urban inhalable particles on allergic rhinitis of rats[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2011, 25(11): 506-509 |
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| Authors: | Xing Zhimin Liu Xiaoling Yu Lisheng Wang Min |
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| Affiliation: | XING Zhimin LIU Xiaoling YU Lisheng WANG Min(Department of Otorhinolaryngology,Peking University People's Hospital,Beijing,100044,China) |
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| Abstract: | Objective:In order to study the effect of inhalable particles on provocation of rat allergic rhinitis model and its possible mechanism.Method:After basicly sensitizing the experimental rats with OVA by intraperitoneal injection,three groups were provocated by solo OVA,PM10+OVA and solo PM10 through nasal cavity respectively.The control group was sensitized by NS instead of OVA,and then provocated by NS as the method of experimental groups.The symptoms of rat during the provocation were observed and recorded... |
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| Keywords: | rhinitis allergic perennial inhalable particles SD rat interleukin-4 |
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