Myoelectric activity and absorptive capacity of rat small intestinal isografts |
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Authors: | Dr. Gordon L. Telford MD Michael A. Nemeth MD Sushil K. Sarna PhD M. Scott Harris MD Krishnamurthy Ramaswamy PhD Wolfgang H. Schraut MD Kenneth K. W. Lee MD Christopher P. Johnson MD Susan Walgenbach-Telford PhD |
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Affiliation: | (1) From the Departments of Surgery and Medicine and Digestive System Research Center, Medical College of Wisconsin and Zablocki Veterans Administration Medical Center Milwaukee, Wisconsin;(2) Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania;(3) Present address: Section of Digestive and Liver Diseases, University of Illinois at Chicago, College of Medicine, Chicago, Illinois |
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Abstract: | The effect of transplantation on small intestinal absorption, digestive capacity, myoelectric activity, and morphology was assessed in inbred Lewis rats. Electrodes were sutured to the duodenum and isografted jejunoileum or to the native jejunoileum in controls. The frequency of migrating myoelectric complexes (MMCs) in the duodenum was 3.3±0.3/hr in controls and 1.8±0.4/hr in transplants (P<0.05). MMC frequency in the jejunoileum was 5.1±1.3/hr in controls and 3.2±0.9/hr in transplants (P>0.05). MMCs appeared to migrate from the duodenum to the jejunoileum 80±3% of the time in controls and 59±7% of the time in transplant rats (P<0.05). Absorption in the transplanted jejunoileum demonstrated a 35–40% decrease in glucose and electrolytes absorption. Villus height and number of nuclei per villus was reduced. Intestinal length (dry) was 103±6 cm for controls and 51±3 cm for transplant rats (P<0.05). Brush border sucrase activity was unchanged. We conclude that small intestinal isografts display similar myoelectric activity as controls, but the decreased absorptive capacity and villus height may require longer segments of intestine to be transplanted in order to support normal nutrition.Supported by the Veterans Administration Research Service. |
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Keywords: | small intestine transplantation gastrointestinal motility intestinal absorption |
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